Mouse Amyloid Beta Peptide 42 Monoclonal Antibody

mAb anti-Amyloid Beta Peptide 42

Cat. Num. AAA14626

• Reactivity: Human and other primates; Mouse, Rat
• Applications: ELISA
• Purity: Protein G affinity purified
• Synonyms: Amyloid Beta Peptide 42, Antibody; mAb anti-Amyloid Beta Peptide 42; Beta amyloid peptide 42; Mouse monoclonal antibody to C-terminal of amyloid beta peptide 42 (Abeta42); anti-Amyloid Beta Peptide 42 antibody

• Host: Mouse
• Reactivity: Human and other primates; Mouse, Rat
• Clonality: Monoclonal
• Isotype: IgG2b,k
• Clone Number: CA9 3B3
• Specificity: This antibody recognizes the C-terminal sequence (MVGGVVIA) of Aβ42 and full length Aβ42.
• Purity/Purification: Protein G affinity purified
• Form/Format: Lyophilized from a solution in 0.01M PBS, pH 7.2

• Applicable Applications for anti-Amyloid Beta Peptide 42 antibody: ELISA (EIA)
• Application Notes: ELISA: In combination with capturer anti-amyloid peptide N-terminal antibody (mAb clone NT 4A2), the antibody can detect Aβ42 in Sandwich ELISA assay.; Immuno-blot: Detect Aβ42 on dot blot using anti- Aβ42 clone CA9 3B3 (1µg/mL) on 10ng /dot of Aβ40 or Aβ42.
• Target Protein: C-terminal of amyloid beta peptide 42
• Immunogen: KLH conjugated to a short peptide (MVGGVVIA) with amino acid sequence corresponding to the C-terminal of Aß42
• Fusion Myeloma: Sp2/0-Ag14
• Reconstitution: Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.
• Research Area: Aging and neurodegenerative diseases
• Cross Reactivity: The antibody does not cross react with amyloid beta peptide 40 in dot blotting and ELISA. Cross-reactivity to amyloid beta peptide 43 is about 5% in ELISA.
• Preparation and Storage: Store at -20°C

Application Data

Related Product Information for anti-Amyloid Beta Peptide 42 antibody

Amyloid beta peptide 42 (Aß42) is best known for its role in the formation of senile plaques in the brain of patients with Alzheimer's disease. Aß42 and Aß40 are the two major amyloid peptides that are produced after cleavage of amyloid precursor protein by secretases. Aß42 (42 amino acids) is very fibrillogenic. The beta pleated structure of Aß42 constituents the initial and key component of the insoluble amyloid fibril in senile plaque. It is widely accepted that Aß42 contributes to the pathogenesis of Alzheimer's disease. One proposition is that the deposition of amyloid fibril onto the brain tissue results in Alzheimer's disease. Another is that the neurotoxicity of Aß42 oligomer is the cause of the disease.

Product Categories/Family for anti-Amyloid Beta Peptide 42 antibody

Primary antibody; Monoclonal Antibodies to Neurological Disorder Proteins