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Mouse anti-Human CDw17 Monoclonal Antibody | anti-CDw17 antibody

CDw17 (Lactosylceramide or LacCer) Mouse Monoclonal Antibody

Reactivity
Human
Applications
Flow Cytometry, Functional Assay, Immunofluorescence
Synonyms
CDw17, Antibody; CDw17 (Lactosylceramide or LacCer) Mouse Monoclonal Antibody; Lactosylceramide; LacCer; --D-galactosyl-(1-4)---D-glucosyl-(1-1')-ceramide; CDw17; anti-CDw17 antibody
Ordering
 
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For Research Use Only!
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgM kappa
Clone Number
HO18.3G-6.F5
Specificity
CD17 is an intermediate glycosphingolipid from the metabolism of higher gangliosides that localizes to sphingolipid-sterol rafts. CD17 is detectable in monocytes, granulocytes, basophils, platelets, a subset of peripheral B cells (CD19+) and tonsil dendritic cells. It is rapidly down regulated on activated granulocytes and is upregulated on IL-2 activated T lymphocytes. CD17 binds to bacteria and may function in phagocytosis. VEGF-treated endothelial cells can produce CD17, which can then mediate signaling toward PECAM-1 expression and angiogenesis. Tumor necrosis factor a (TNFa)-induced astrogliosis (astrocyte proliferation and glial fibrillary acidic protein (GFAP) upregulation) in response to neuro-inflammation (i.e. spinal cord injury) causes an increase in intracellular levels of CD17. Aberrant levels of glycosphingolipids are a feature of cancer cells and may influence integrin clustering and internalization.
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide.
Applicable Applications for anti-CDw17 antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF)
Application Notes
Flow Cytometry: 1-2ug/million cells
Immunofluorescence: 1-3ug/ml

Optimal dilutions for a specific application should be determined.
Immunogen
beta-2 Microglobulin associated proteins from a detergent lysate of human PBL
Positive Control
Human PBL. Tonsil
Preparation and Storage
Antibody with azide , store at 2-8 degree C. Non-hazardous. No MSDS required.
References
Lovering, K.E. Characterisation of the Tcell surface by monoclonal antibodies. PhD thesis, University of Melbourne, 1985. Knapp W. Leukocyte Typing IV, Oxford Univ. Press, pp. 810811, 1989. Also data on M119, pp 861, 874, 877 879, 897, 907, 923, 925

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Product Notes

The CDw17 (Catalog #AAA13832) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CDw17 (Lactosylceramide or LacCer) Mouse Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CDw17 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Immunofluorescence (IF). Flow Cytometry: 1-2ug/million cells Immunofluorescence: 1-3ug/ml Optimal dilutions for a specific application should be determined. Researchers should empirically determine the suitability of the CDw17 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CDw17, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.