<
Rabbit TIE2 Polyclonal Antibody | anti-TIE2 antibody
TIE2 Polyclonal Antibody
Gene Names
TEK; TIE2; VMCM; TIE-2; VMCM1; CD202B
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry
Synonyms
TIE2, Antibody; TIE2 Polyclonal Antibody; Angiopoietin-1 receptor (EC 2.7.10.1)(Endothelial tyrosine kinase)(Tunica interna endothelial cell kinase)(Tyrosine kinase with Ig and EGF homology domains-2)(Tyrosine-protein kinase receptor TEK)(Tyrosine-protein kinase receptor TIE-2)(hTIE2)(p140 TEK)(CD antigen CD202b); anti-TIE2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Applicable Applications for anti-TIE2 antibody
Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P)
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohistochemistry)
(Dilution: IHC-p: 100-300.WB 1:500-2000, ELISA 1:10000-20000)
IHC (Immunohistchemistry)
(Dilution: IHC-p: 100-300.WB 1:500-2000, ELISA 1:10000-20000)
IHC (Immunohistochemistry)
(Dilution: IHC-p: 100-300.WB 1:500-2000, ELISA 1:10000-20000)
IHC (Immunohistochemistry-Paraffin)
(Dilution: IHC-p: 100-300.WB 1:500-2000, ELISA 1:10000-20000)
IHC (Immunohistochemistry-Paraffin)
(Dilution: IHC-p: 100-300.WB 1:500-2000, ELISA 1:10000-20000)
IHC (Immunohistochemistry-Paraffin)
(Dilution: IHC-p: 100-300.WB 1:500-2000, ELISA 1:10000-20000)
IHC (Immunohistochemistry)
(Dilution: IHC-p: 100-300.WB 1:500-2000, ELISA 1:10000-20000)
Related Product Information for anti-TIE2 antibody
Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post- natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, andultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1; SHC1 and TIE1.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
125,830 Da
NCBI Official Full Name
angiopoietin-1 receptor
NCBI Official Synonym Full Names
TEK tyrosine kinase, endothelial
NCBI Official Symbol
TEK
NCBI Official Synonym Symbols
TIE2; VMCM; TIE-2; VMCM1; CD202B
NCBI Protein Information
angiopoietin-1 receptor; hTIE2; p140 TEK; soluble TIE2 variant 1; soluble TIE2 variant 2; endothelial tyrosine kinase; tyrosine-protein kinase receptor TEK; tunica interna endothelial cell kinase; tyrosine-protein kinase receptor TIE-2; tyrosine kinase wi
UniProt Protein Name
Angiopoietin-1 receptor
UniProt Gene Name
TEK
UniProt Synonym Gene Names
TIE2; VMCM; VMCM1; hTIE2
UniProt Entry Name
TIE2_HUMAN
