Rabbit DOCK4 Polyclonal Antibody | anti-DOCK4 antibody

DOCK4 Antibody

Cat. Num. AAA29930

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunocytochemistry, Immunohistochemistry
• Purity: Peptide affinity purified
• Synonyms: DOCK4, Antibody; DOCK4 Antibody; Dedicator of cytokinesis protein 4 antibody; Dock4 antibody; DOCK4_HUMAN antibody; KIAA0716 antibody; anti-DOCK4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Peptide affinity purified
• Form/Format: 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.

• Applicable Applications for anti-DOCK4 antibody: Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200; ICC: 1:50-1:200
• Immunogen: Peptide
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C.

ICC (Immunocytochemistry)

(ICC staining DOCK4 in HUVEC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.)

ICC (Immunocytochemistry)

(ICC staining DOCK4 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.)

ICC (Immunocytochemistry)

(ICC staining DOCK4 in PC-3M cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.)

IHC (Immunohistochemistry)

(Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue using anti-DOCK4 antibody. Counter stained with hematoxylin.)

IHC (Immunohistochemistry)

(Immunohistochemical analysis of paraffin-embedded human fetal skeletal muscle tissue using anti-DOCK4 antibody. Counter stained with hematoxylin.)

IHC (Immunohistochemistry)

(Immunohistochemical analysis of paraffin-embedded rat skeletal muscle tissue using anti-DOCK4 antibody. Counter stained with hematoxylin.)

IHC (Immunohistochemistry)

(Immunohistochemical analysis of paraffin-embedded human prostate tissue using anti-DOCK4 antibody. Counter stained with hematoxylin.)

Related Product Information for anti-DOCK4 antibody

DOCK 4 (Dedicator of cytokinesis protein 4) is a cytoplasmic peripheral membrane protein that belongs to the DOCK family of cytokinesis-regulating proteins. Expressed ubiquitously with highest expression in prostate, ovary and skeletal muscle, DOCK 4 functions as a guanine nucleotide exchange factor (GEF) that activates the small GTPase Rap 1 and, via this activation, plays a role in the regulation of adherens junctions between cells. Similar to other DOCK family members, DOCK 4 contains an N-terminal SH3 domain, a C-terminal proline-rich region and two internal DOCK homology regions designated DHR1 and DHR2. Defects in the gene encoding DOCK 4 result in the inactivation of Rap 1 and are, thus, implicated in the pathogenesis of various cancers such as ovarian, prostate, glioma and colorectal carcinomas. Four isoforms of DOCK 4 are expressed due to alternative splicing events.

Product Categories/Family for anti-DOCK4 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 92091572
• NCBI GeneID: 9732
• NCBI Accession #: NP_055520.3
• NCBI GenBank Nucleotide #: NM_014705.3
• UniProt Accession #: Q8N1I0; O14584; O94824; Q8NB45
• Molecular Weight: 29,833 Da
• NCBI Official Full Name: dedicator of cytokinesis protein 4
• NCBI Official Synonym Full Names: dedicator of cytokinesis 4
• NCBI Official Symbol: DOCK4
• NCBI Protein Information: dedicator of cytokinesis protein 4
• UniProt Protein Name: Dedicator of cytokinesis protein 4
• UniProt Gene Name: DOCK4
• UniProt Synonym Gene Names: KIAA0716