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Rabbit anti-Human, Mouse TIA1 Monoclonal Antibody | anti-TIA1 antibody
TIA1 Antibody
Gene Names
TIA1; WDM; TIA-1
Reactivity
Human, Mouse
Applications
Western Blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation
Purity
ProA affinity purified
Synonyms
TIA1, Antibody; TIA1 Antibody; Cytotoxic granule associated RNA binding protein 1 antibody; Cytotoxic granule associated RNA binding protein antibody; mTIA-1 antibody; Nucleolysin TIA 1 isoform p40 antibody; Nucleolysin TIA-1 isoform p40 antibody; Nucleolysin TIA1 isoform p40 antibody; p40 TIA 1 antibody; p40-TIA-1 (containing p15-TIA-1) antibody; p40-TIA-1 antibody; RNA binding protein TIA 1 antibody; RNA binding protein TIA1 antibody; RNA-binding protein TIA-1 antibody; T-cell-restricted intracellular antigen-1 antibody; TIA 1 antibody; TIA 1 cytotoxic granule associated RNA binding protein antibody; Tia antibody; TIA-1 antibody; TIA1 antibody; TIA1 cytotoxic granule associated RNA binding protein antibody; TIA1 cytotoxic granule associated RNA binding protein like 1 antibody; TIA1 protein antibody; TIA1_HUMAN antibody; TIAL1 antibody; TIAR antibody; WDM antibody; anti-TIA1 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Monoclonal
Clone Number
JM42-11
Purity/Purification
ProA affinity purified
Form/Format
1*TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Applicable Applications for anti-TIA1 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP)
Application Notes
WB: 1:500-1:1000
IHC: 1:50-1:200
ICC: 1:50-1:200
IP: 1:10-1:50
IHC: 1:50-1:200
ICC: 1:50-1:200
IP: 1:10-1:50
Antibody Type
Recombinant Antibody
Immunogen
Recombinant protein
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C.
ICC (Immunocytochemistry)
(ICC staining TIA1 in Hela cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.)
ICC (Immunocytochemistry)
(ICC staining TIA1 in A431 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.)
ICC (Immunocytochemistry)
(ICC staining TIA1 in 293T cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.)
IHC (Immunohistochemistry)
(Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-TIA1 antibody. Counter stained with hematoxylin.)
IHC (Immunohistochemistry)
(Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-TIA1 antibody. Counter stained with hematoxylin.)
WB (Western Blot)
(Western blot analysis of TIA1 on Jurkat cells lysates using anti-TIA1 antibody at 1/500 dilution.)
Related Product Information for anti-TIA1 antibody
FAS, also referred to as CD95 or APO-1, is a type I transmembrane protein that plays a central role mediating viral immunity. TIA-1 and TIAR are two closely related proteins that possess three RRMs (RNA recognition motifs), designated RRM 1, 2 and 3. Although both TIA-1 and TIAR are thought to function as mediators of apoptotic cell death, their specific roles in such pathways are unknown. Unlike TIA-1, which is found in the granules of cytotoxic lymphocytes, TIAR expression is limited to the nucleus and found in a much broader range of cells including, but not limited to, cells of hematopoietic origin. TIAR is translocated to the cytoplasm shortly after FAS ligation and this event immediately proceeds the onset of DNA fragmentation. A novel serine/threonine kinase that is activated as a result of FAS ligation, designated FAST (FAS-activated serine/threonine), shows kinase specificity towards both TIA-1 and TIAR. In unstimulated Jurkat cells, FAST resides in the cytoplasm as a highly phosphorylated protein and is quickly dephosphorylated and activated in response to stimulated FAS.
Product Categories/Family for anti-TIA1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
41,801 Da
NCBI Official Full Name
Nucleolysin TIA-1 isoform p40
NCBI Official Synonym Full Names
TIA1 cytotoxic granule-associated RNA binding protein
NCBI Official Symbol
TIA1
NCBI Official Synonym Symbols
WDM; TIA-1
NCBI Protein Information
nucleolysin TIA-1 isoform p40; p40-TIA-1 (containing p15-TIA-1); T-cell-restricted intracellular antigen-1
UniProt Protein Name
Nucleolysin TIA-1 isoform p40
UniProt Gene Name
TIA1
UniProt Synonym Gene Names
TIA-1
UniProt Entry Name
TIA1_HUMAN
