Application Data
CD4 ectodomain Recombinant Protein | CD4 recombinant protein
Human CD4 ectodomain protein (amino acid 1-398)
Gene Names
CD4; CD4mut
Applications
ELISA, Western Blot
Purity
> 95% (SDS-PAGE)
Synonyms
CD4 ectodomain; N/A; Human CD4 ectodomain protein (amino acid 1-398); Human CD4 ectodomain protein; glycosylated; Human CD4 (Ectodomain) Protein; Human CD4 ectodomain protein (aa1-398), glycosylated; CD4 recombinant protein
Host
Human CD4 protein expressed and purified from 293 cell culture
Purity/Purification
> 95% (SDS-PAGE)
Concentration
1 mg/ml in PBS with less than 0.1% BSA and 25% glycerol (varies by lot)
Sequence Length
458
Applicable Applications for CD4 recombinant protein
Immunogen, ELISA, WB (Western Blot)
Viral Protein
C-terminal 6xHis tagged human CD4 ectodomain glycoprotein (amino acid 26-398) (Genebank No. NP_000607.1)
Preparation and Storage
Store at -20 degree C. Stable for 6-months from the date of shipment when kept at 4 degree C. Non-hazardous. No MSDS required.
Application Data
Application Data
Related Product Information for CD4 recombinant protein
Description: 6xHis tagged human CD4 ectodomain protein (amino acid 1-398) (Genebank No. P01730)
Human CD4 ectodomain glycoprotein expressed and purified from 293 cell culture
Introduction: CD4 (cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. CD4+ T helper cells are white blood cells that are an essential part of the human immune system. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system.
HIV-1 uses CD4 to gain entry into host T-cells and achieves this through its viral envelope protein known as gp120. The binding to CD4 creates a shift in the conformation of gp120 allowing HIV-1 to bind to a co-receptor expressed on the host cell. These co-receptors are chemokine receptors CCR5 or CXCR4. Following a structural change in another viral protein (gp41), HIV inserts a fusion peptide into the host cell that allows the outer membrane of the virus to fuse with the cell membrane.
Human CD4 ectodomain glycoprotein expressed and purified from 293 cell culture
Introduction: CD4 (cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. CD4+ T helper cells are white blood cells that are an essential part of the human immune system. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system.
HIV-1 uses CD4 to gain entry into host T-cells and achieves this through its viral envelope protein known as gp120. The binding to CD4 creates a shift in the conformation of gp120 allowing HIV-1 to bind to a co-receptor expressed on the host cell. These co-receptors are chemokine receptors CCR5 or CXCR4. Following a structural change in another viral protein (gp41), HIV inserts a fusion peptide into the host cell that allows the outer membrane of the virus to fuse with the cell membrane.
Product Categories/Family for CD4 recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
51,111 Da
NCBI Official Full Name
T-cell surface glycoprotein CD4
NCBI Official Synonym Full Names
CD4 molecule
NCBI Official Symbol
CD4
NCBI Official Synonym Symbols
CD4mut
NCBI Protein Information
T-cell surface glycoprotein CD4; CD4 antigen (p55); CD4 receptor; T-cell surface antigen T4/Leu-3
UniProt Protein Name
T-cell surface glycoprotein CD4
UniProt Gene Name
CD4
UniProt Entry Name
CD4_HUMAN
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Product Notes
The CD4 cd4 (Catalog #AAA62185) is a Recombinant Protein produced from Human CD4 protein expressed and purified from 293 cell culture and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's CD4 ectodomain can be used in a range of immunoassay formats including, but not limited to, Immunogen, ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the CD4 cd4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD4 ectodomain, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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