HDAC6 recombinant protein

HDAC6, Active

Cat. Num. AAA73603

• Gene Names: HDAC6; HD6; JM21
• Applications: Western Blot
• Synonyms: HDAC6; N/A; HDAC6, Active; HD6; JM21; KIAA0901; HDAC6 recombinant protein

• Host: Sf9 insect cells
• Form/Format: Recombinant protein stored in 50mM Tris-HCl, pH7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

• Applicable Applications for HDAC6 recombinant protein: WB (Western Blot), HDAC (Histone Deacetylase Assay)
• Tag: GST
• Species: Human
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
• Preparation and Storage: Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

SDS-PAGE

(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)

Activity

(Specific Activity: Sample Histone Deacetylase Activity Plot. For specific information on a given lot, see related technical data sheet.)

Related Product Information for HDAC6 recombinant protein

Recombinant full-length human HDAC6 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is BC069243.
HDAC6 or Histone deacetylase 6 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. The protein encoded by this gene belongs to class II of the histone deacetylase family that regulates important biologic processes beyond histone metabolism and gene transcription (1). HDAC6 is a central component of the stress response that regulates SG formation and potentially contributes to control of RNA metabolism and translation (2).

Product Categories/Family for HDAC6 recombinant protein

Histone Deacetylases; Cancer; Cell Cycle; Inflammation

References

1. Hubbert, C. et.al: HDAC6 is a microtubule-associated deacetylase. Nature 417: 455-458, 2002.
2. Kwon, S. et.al: The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response. Genes Dev. 21: 3381-3394, 2007.

NCBI and Uniprot Product Information

• NCBI GI #: 46623326
• NCBI GeneID: 10013
• UniProt Accession #: Q9UBN7; O94975; Q6NT75; Q7L3E5; Q96CY0
• Molecular Weight: 159 kDa
• NCBI Official Full Name: Homo sapiens histone deacetylase 6, mRNA
• NCBI Official Synonym Full Names: histone deacetylase 6
• NCBI Official Symbol: HDAC6
• NCBI Official Synonym Symbols: HD6; JM21
• NCBI Protein Information: histone deacetylase 6
• UniProt Protein Name: Histone deacetylase 6
• UniProt Gene Name: HDAC6
• UniProt Synonym Gene Names: KIAA0901; HD6
• UniProt Entry Name: HDAC6_HUMAN