Application Data
(Measured by its ability to bind rat Fc-VEGFC in functional ELISA.)
Neuropilin-2 Active Protein | NRP2 active protein
Neuropilin-2 Protein, Mouse, Recombinant (His Tag)
Gene Names
Nrp2; Np2; Np-2; Npn2; Npn-2; 1110048P06Rik
Purity
>95% as determined by SDS-PAGE
Synonyms
Neuropilin-2; N/A; Neuropilin-2 Protein, Mouse, Recombinant (His Tag); Mouse Neuropilin-2/NRP2 Protein (His Tag); 1110048P06Rik Protein, Mouse; Np-2 Protein, Mouse; Np2 Protein, Mouse; Npn-2 Protein, Mouse; Npn2 Protein, Mouse; neuropilin 2; NRP2 active protein
Host
HEK293 Cells
Purity/Purification
>95% as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Sequence
Met1-Pro864
Species
Mouse
Endotoxin
<1.0EU per ug protein as determined by the LAL method.
Predicted N Terminal
Arg 21
Tag
C-His
Protein Construction
A DNA sequence encoding the mouse NRP2 (NP_001070871.1)(Met1-Pro864) was expressed with a polyhistidine tag at the C-terminus.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Activity
Measured by its ability to bind rat Fc-VEGFC in functional ELISA.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.
They are shipped out with blue ice.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.
They are shipped out with blue ice.
Application Data
(Measured by its ability to bind rat Fc-VEGFC in functional ELISA.)
Application Data
(Measured by its ability to bind rat Fc-VEGFC in functional ELISA.)
SDS-PAGE
SDS-PAGE
Related Product Information for NRP2 active protein
Background: Neuropilin-2 (NRP-2) which is related to NRP-1, is a type I transmembrane glycoprotein and has the structure characteristic with five main extracellular domains: two complement binding (CUB) domains, two coagulation factor V/VIII homology domains, and a MAM (meprin, tyrosine phosphatase domain) region. NRP-2 is a receptor capable of binding two disparate ligands, classI¢ semaphorins (SEMA) and vascular endothelial growth factors (VEGF), and thus regulates two diverse systems by activating cellular signaling pathways via interacting with other cell surface receptors such as VEGF receptors and plexins. NRP-2 is well known for its role in facilitating axonal guidance during the development of the neuronal system, and additionally, it is also expressed in vascular endothelial cells and lymphatic endothelium where it affects proliferation, migration, angiogenesis, as well as the formation of small lymphatic vessels and capillaries. A recent study has identified NRP-2 as a polysialylation protein expressed in human dendritic cells and modulates DC-T Cell Interactions. Nearly all tumor cells express neuropilins and NRP-2 is predominantly expressed in neuronal tumors and melanomas. Furthermore, it is suggested that as the specific ligand for NRP-2, SEMA 3F inhibits tumor angiogenesis, and metastasis.
References
Chen H. et al., 1997, Neuron. 19: 547-59. Bielenberg DR. et al., 2006, Exp Cell Res. 312: 584-93. Yuan L. et al., 2002, Development. 129: 4797-806. Benoit F. et al., 2006, Blood. 108: 1243-50. Sabrina C. et al., 2007, J Biol Chem. 282: 30346-56. Gray MJ. et al., 2008, J Natl Cancer Inst. 100: 109-20.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
104,631 Da
NCBI Official Full Name
neuropilin-2 isoform 1
NCBI Official Synonym Full Names
neuropilin 2
NCBI Official Symbol
Nrp2
NCBI Official Synonym Symbols
Np2; Np-2; Npn2; Npn-2; 1110048P06Rik
NCBI Protein Information
neuropilin-2; vascular endothelial cell growth factor 165 receptor 2
UniProt Protein Name
Neuropilin-2
UniProt Gene Name
Nrp2
UniProt Entry Name
NRP2_MOUSE
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Product Notes
The NRP2 nrp2 (Catalog #AAA258245) is an Active Protein produced from HEK293 Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Met1-Pro86 4. It is sometimes possible for the material contained within the vial of "Neuropilin-2, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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