LOXL2 recombinant protein

Recombinant Human LOXL2 Protein (His Tag), HPLC-verified

Cat. Num. AAA259321

• Gene Names: LOXL2; LOR2; WS9-14
• Reactivity: Human
• Purity: >= 95% as determined by SDS-PAGE. >= 95% as determined by SEC-HPLC.
• Synonyms: LOXL2; N/A; Recombinant Human LOXL2 Protein (His Tag), HPLC-verified; Human LOXL2/Lysyl oxidase homolog 2 Protein (His Tag); lysyl oxidase-like 2; LOR Protein, Human; LOR2 Protein, Human; WS9-14 Protein, Human; LOXL2 recombinant protein

• Host: CHO Stable Cells
• Reactivity: Human
• Purity/Purification: >= 95% as determined by SDS-PAGE. >= 95% as determined by SEC-HPLC.
• Form/Format: Lyophilized from sterile 20 mM MES, 50 mM NaClPlease contact us for any concerns or special requirements. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Sequence: Met1-Gln774

• Tag: C-His
• Predicted N Terminal: Gln 26
• Endotoxin: < 1.0 EU perug protein as determined by the LAL method.
• Activity: Measured by its ability to produce hydrogen peroxide during the oxidation of benzylamine. The specific activity is >2pmol/min/ug
• Protein Construction: A DNA sequence encoding the human LOXL2 (Q9Y4K0)(Met1-Gln774) was expressed, fused with a polyhistidine tag at the C-terminus.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Application Data

Application Data

Related Product Information for LOXL2 recombinant protein

Lysyl oxidase homolog 2, also known as Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14 and LOXL2, is a secreted protein that belongs to the lysyl oxidase family. LOXL2 contains four SRCR domains. The lysyl oxidase family is made up of five members: lysyl oxidase (LOX) and lysyl oxidase-like 1-4 (LOXL1, LOXL2, LOXL3, LOXL4). All members share conserved C-terminal catalytic domains that provide for lysyl oxidase or lysyl oxidase-like enzyme activity; and more divergent propeptide regions. LOX family enzyme activities catalyze the final enzymatic conversion required for the formation of normal biosynthetic collagen and elastin cross-links. LOXL2 is expressed by pre-hypertrophic and hypertrophic chondrocytes in vivo, and that LOXL2 expression is regulated in vitro as a function of chondrocyte differentiation. LOXL2 promotes chondrocyte differentiation by mechanisms that are likely to include roles as both a regulator and an effector of chondrocyte differentiation. LOXL2 expression could also be explored as a molecular target in the prevention of breast cancer progression.

References

Peng,L. e. al.. 2009. Carcinogenesis. 3. (10):1660-9. Hollosi,P. e. al.. 2009. In. . Cancer. 125(2):318-27. Rückert,F.e. al.. 2010. In. . Colorecta. Dis. 25(3):303-11. Iftikhar,M. e. al.,2011. . Bio. Chem. 286(2):909-18.

NCBI and Uniprot Product Information

• NCBI GI #: 4505011
• NCBI GeneID: 4017
• NCBI Accession #: NP_002309.1
• NCBI GenBank Nucleotide #: NM_002318.2
• UniProt Accession #: Q9Y4K0; Q53HV3; Q9BW70; Q9Y5Y8; B2R5Q0
• Molecular Weight: 86,725 Da
• NCBI Official Full Name: lysyl oxidase homolog 2
• NCBI Official Synonym Full Names: lysyl oxidase like 2
• NCBI Official Symbol: LOXL2
• NCBI Official Synonym Symbols: LOR2; WS9-14
• NCBI Protein Information: lysyl oxidase homolog 2
• UniProt Protein Name: Lysyl oxidase homolog 2
• UniProt Gene Name: LOXL2
• UniProt Entry Name: LOXL2_HUMAN