Methyl CpG Binding Protein 2 Recombinant Protein | MECP2 recombinant protein
Recombinant Human Methyl CpG Binding Protein 2
Gene Names
MECP2; RS; RTS; RTT; PPMX; MRX16; MRX79; MRXSL; AUTSX3; MRXS13
Purity
Greater than 80% as determined by SDS-PAGE.
Synonyms
Methyl CpG Binding Protein 2; N/A; Recombinant Human Methyl CpG Binding Protein 2; MECP2 Human; Methyl CpG Binding Protein 2 Human Recombinant; Methyl CpG binding protein 2 (Rett syndrome); MeCp-2 protein; AUTSX3; MRX16; MRX79; MRXS13; MRXSL; PPMX; RTT; Mental retardation; X-linked 16; DKFZp686A24160; MECP2 recombinant protein
Host
Mammalian system, 293 cells
Purity/Purification
Greater than 80% as determined by SDS-PAGE.
Form/Format
The MECP2 solution (0.45mg/ml) contains 50mM Tris, 135mM NaCl, 20% Glycerol, pH 7.5 and 200 ug/ml DYKDDDDK peptide.
Sterile Filtered colorless solution.
Sterile Filtered colorless solution.
Sequence
MDYKDDDDKMVAGMLGLREEKSEDQDLQGLKDKPLKFKKVKKDKKEEKEGKHEPVQPSAHHSAEPAEAGKAETSEGSGSAPAVPEASASPKQRRSIIRDRGPMYDDPTLPEGWTRKLKQRKSGRSAGKYDVYLINPQGKAFRSKVELIAYFEKVGDTSLDPNDFDFTVTGRGSPSRREQKPPKKPKSPKAPGTGRGRGRPKGSGTTRPKAATSEGVQVKRVLEKSPGKLLVKMPFQTSPGGKAEGGGATTSTQVMVIKRPGRKRKAEADPQAIPKKRGRKPGSVVAAAAAEAKKKAVKESSIRSVQETVLPIKKRKTRETVSIEVKEVVKPLLVSTLGEKSGKGLKTCKSPGRKSKESSPKGRSSSASSPPKKEHHHHHHHSESPKAPVPLLPPLPPPPPEPESSEDPTSPPEPQDLSSSVCKEEKMPRGGSLESDGCPKEPAKTQPAVATAATAAEKYKHRGEGERKDIVSSSMPRPNREEPVDSRTPVTERVS
Sequence Length
498
Preparation and Storage
MECP2 although stable 4 degree C for 4 weeks, should be stored below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Related Product Information for MECP2 recombinant protein
Description: MECP2 Human Recombinant is expressed in 293 cells. The protein contains 486 amino acids (1-486a.a.) and fused to an N-terminal DYKDDDDK tag, having an Mw of 53.56kDa.
Introduction: MECP2 is the key modificator of eukaryotic genomes and has a crucial part in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 form a family of nuclear proteins linked by the existence in each of a methyl-CpG binding domain (MBD). Each one of these proteins, with the exception of MBD3, can bind specifically to methylated DNA. In addition, MECP2, MBD1 and MBD2 can inhibit transcription from methylated gene promoters. Unlike other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is expendable in stem cells, but is vital for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common reasons of mental retardation in females.
Introduction: MECP2 is the key modificator of eukaryotic genomes and has a crucial part in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 form a family of nuclear proteins linked by the existence in each of a methyl-CpG binding domain (MBD). Each one of these proteins, with the exception of MBD3, can bind specifically to methylated DNA. In addition, MECP2, MBD1 and MBD2 can inhibit transcription from methylated gene promoters. Unlike other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is expendable in stem cells, but is vital for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common reasons of mental retardation in females.
Product Categories/Family for MECP2 recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
53,323 Da
NCBI Official Full Name
methyl-CpG-binding protein 2 isoform 2
NCBI Official Synonym Full Names
methyl CpG binding protein 2
NCBI Official Symbol
MECP2
NCBI Official Synonym Symbols
RS; RTS; RTT; PPMX; MRX16; MRX79; MRXSL; AUTSX3; MRXS13
NCBI Protein Information
methyl-CpG-binding protein 2; meCp-2 protein
UniProt Protein Name
Methyl-CpG-binding protein 2
UniProt Gene Name
MECP2
UniProt Synonym Gene Names
MeCp-2 protein; MeCp2
UniProt Entry Name
MECP2_HUMAN
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Product Notes
The MECP2 mecp2 (Catalog #AAA38958) is a Recombinant Protein produced from Mammalian system, 293 cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MDYKDDDDK< /u>MVAGMLG LREEKSEDQD LQGLKDKPLK FKKVKKDKKE EKEGKHEPVQ PSAHHSAEPA EAGKAETSEG SGSAPAVPEA SASPKQRRSI IRDRGPMYDD PTLPEGWTRK LKQRKSGRSA GKYDVYLINP QGKAFRSKVE LIAYFEKVGD TSLDPNDFDF TVTGRGSPSR REQKPPKKPK SPKAPGTGRG RGRPKGSGTT RPKAATSEGV QVKRVLEKSP GKLLVKMPFQ TSPGGKAEGG GATTSTQVMV IKRPGRKRKA EADPQAIPKK RGRKPGSVVA AAAAEAKKKA VKESSIRSVQ ETVLPIKKRK TRETVSIEVK EVVKPLLVST LGEKSGKGLK TCKSPGRKSK ESSPKGRSSS ASSPPKKEHH HHHHHSESPK APVPLLPPLP PPPPEPESSE DPTSPPEPQD LSSSVCKEEK MPRGGSLESD GCPKEPAKTQ PAVATAATAA EKYKHRGEGE RKDIVSSSMP RPNREEPVDS RTPVTERVS. It is sometimes possible for the material contained within the vial of "Methyl CpG Binding Protein 2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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