Mouse Bax Monoclonal Antibody | anti-Bax antibody

Bax mouse Monoclonal Antibody (6F11)

Cat. Num. AAA28907

• Gene Names: BAX; BCL2L4
• Reactivity: Human, Mouse, Rat, Chicken
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Synonyms: Bax, Antibody; Bax mouse Monoclonal Antibody (6F11); BAX; anti-Bax antibody

• Host: Mouse
• Reactivity: Human, Mouse, Rat, Chicken
• Clonality: Monoclonal
• Clone Number: 6F11

• Applicable Applications for anti-Bax antibody: Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P), Immunofluorescence (IF)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

WB (Western Blot)

(Dilution: IF: 1:50-200 WB 1:1000-2000, IHC 1:100-200)

Application Data

(Dilution: IF: 1:50-200 WB 1:1000-2000, IHC 1:100-200)

Application Data

(Dilution: IF: 1:50-200 WB 1:1000-2000, IHC 1:100-200)

Application Data

(Dilution: IF: 1:50-200 WB 1:1000-2000, IHC 1:100-200)

Application Data

(Dilution: IF: 1:50-200 WB 1:1000-2000, IHC 1:100-200)

IHC (Immunohistochemistry-Paraffin)

(Dilution: IF: 1:50-200 WB 1:1000-2000, IHC 1:100-200)

IF (Immunofluorescence)

(Dilution: IF: 1:50-200 WB 1:1000-2000, IHC 1:100-200)

Related Product Information for anti-Bax antibody

Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM)(PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

NCBI and Uniprot Product Information

• NCBI GI #: 4757838
• NCBI GeneID: 581
• NCBI Accession #: NP_004315.1
• NCBI GenBank Nucleotide #: NM_004324.3
• UniProt Accession #: Q07812; P55269; Q07814; Q07815; Q8WZ49; Q9NR76; Q9NYG7; Q9UCZ6; Q9UCZ7; Q9UQD6; A8K4W1
• Molecular Weight: 21,184 Da
• NCBI Official Full Name: apoptosis regulator BAX isoform beta
• NCBI Official Synonym Full Names: BCL2-associated X protein
• NCBI Official Symbol: BAX
• NCBI Official Synonym Symbols: BCL2L4
• NCBI Protein Information: apoptosis regulator BAX; bcl2-L-4; bcl-2-like protein 4; BCL2-associated X protein omega; BCL2-associated X protein transcript variant delta2
• UniProt Protein Name: Apoptosis regulator BAX
• UniProt Gene Name: BAX
• UniProt Synonym Gene Names: BCL2L4; Bcl2-L-4
• UniProt Entry Name: BAX_HUMAN