Application Data
PIK3C2B recombinant protein
PIK3C2B, Active
Gene Names
PIK3C2B; C2-PI3K
Applications
Kinase Assay
Synonyms
PIK3C2B; N/A; PIK3C2B, Active; PIK3C2B recombinant protein
Host
Sf9 insect cells using baculovirus
Form/Format
50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Sequence Positions
850-end
Sequence Length
7319
Applicable Applications for PIK3C2B recombinant protein
Kinase Assay
Species
Human
Tag
GST tag
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store product at -70 degree C.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Application Data
Application Data
Application Data
Application Data
Related Product Information for PIK3C2B recombinant protein
Description: Recombinant human PIK3C2B (850-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Scientific Background: PIK3C2B or phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta belongs to the phosphoinositide 3-kinase (PI3K) family. PIK3C2B plays a role in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. PIK3C2B is highly expressed in thymus and placenta and it may function in a calcium-independent manner (1). In cell signaling, PIK3C2B stabilizes nucleotide-free Ras and the interaction of Ras and PI3KC2beta mutually inhibits one another activity (2).
Scientific Background: PIK3C2B or phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta belongs to the phosphoinositide 3-kinase (PI3K) family. PIK3C2B plays a role in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. PIK3C2B is highly expressed in thymus and placenta and it may function in a calcium-independent manner (1). In cell signaling, PIK3C2B stabilizes nucleotide-free Ras and the interaction of Ras and PI3KC2beta mutually inhibits one another activity (2).
Product Categories/Family for PIK3C2B recombinant protein
References
1. Brown, R. A.et.al: Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K. Biochem. Biophys. Res. Commun. 233: 537-544, 1997. 2. Wong KA. et.al: A new dimension to Ras function: a novel role for nucleotide-free Ras in Class II phosphatidylinositol 3-kinase beta (PI3KC2beta) regulation. PLoS One. 2012;7 (9):e45360. doi: 10.1371/journal.pone.0045360. Epub 2012 Sep 13.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
98 kDa
NCBI Official Full Name
Homo sapiens phosphoinositide-3-kinase, class 2, beta polypeptide, mRNA
NCBI Official Synonym Full Names
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
NCBI Official Symbol
PIK3C2B
NCBI Official Synonym Symbols
C2-PI3K
NCBI Protein Information
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
UniProt Protein Name
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
UniProt Gene Name
PIK3C2B
UniProt Synonym Gene Names
PI3K-C2-beta; PtdIns-3-kinase C2 subunit beta
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Product Notes
The PIK3C2B pik3c2b (Catalog #AAA73051) is a Recombinant Protein produced from Sf9 insect cells using baculovirus and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 850-end. AAA Biotech's PIK3C2B can be used in a range of immunoassay formats including, but not limited to, Kinase Assay. Researchers should empirically determine the suitability of the PIK3C2B pik3c2b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PIK3C2B, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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