IHC (Immunohistochemistry)
(ERV3 Antibody (C-Term) immunohistochemistry analysis in formalin fixed and paraffin embedded human skin tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ERV3 Antibody (C-Term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit anti-Human ERV3 Polyclonal Antibody | anti-ERV3-1 antibody
ERV3 Antibody (C-Term)
Gene Names
ERV3-1; ERV3; ERVR; envR; ERV-R; HERVR; HERV-R
Reactivity
Human
Applications
ELISA, Immunohistochemistry, Western Blot
Purity
This antibody is purified through a protein A column, followed by peptide affinity purification.
Synonyms
ERV3, Antibody; ERV3 Antibody (C-Term); Endogenous retrovirus group 3 member 1 Env polyprotein; ERV-3 envelope protein; ERV3 envelope protein; ERV3-1 envelope protein; Envelope polyprotein; HERV-R envelope protein; ERV-R envelope protein; HERV-R_7q212 provirus ancestral Env polyprotein; Surface protein; SU; Transmembrane protein; TM; ERV3-1; ERV3; anti-ERV3-1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
This ERV3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 445-474 amino acids from the C-terminal region of human ERV3.
Purity/Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Sequence Length
604
Applicable Applications for anti-ERV3-1 antibody
ELISA (EIA), Immunohistochemistry Paraffin (IHC-P), Western Blot (WB)
Application Notes
WB~~1:1000
IHC-P~~1:10~50
IHC-P~~1:10~50
Tissue Location
Expressed at higher level in adrenal, sebaceous glands and placenta. Expressed at lower level in bone narrow, brain, breast, colon, heart, kidney, liver, lung, ovary, PBL, prostate, skin, spleen, testis, thymus, thyroid, trachea
Immunogen Region
445-474
Cellular Location
Virion
Function
Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its fusogenic properties. It can inhibit cell growth through decrease expression of cyclin B1 and increased expression of p21 in vitro.
Preparation and Storage
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohistochemistry)
(ERV3 Antibody (C-Term) immunohistochemistry analysis in formalin fixed and paraffin embedded human skin tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ERV3 Antibody (C-Term) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohistochemistry)
(ERV3 Antibody (C-Term) immunohistochemistry analysis in formalin fixed and paraffin embedded human skin tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ERV3 Antibody (C-Term) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(ERV3 Antibody (C-Term) western blot analysis in 293,HepG2 cell line lysates (35ug/lane).This demonstrates the ERV3 antibody detected the ERV3 protein (arrow).)
WB (Western Blot)
(ERV3 Antibody (C-Term) western blot analysis in 293,HepG2 cell line lysates (35ug/lane).This demonstrates the ERV3 antibody detected the ERV3 protein (arrow).)
Related Product Information for anti-ERV3-1 antibody
The human genome includes many retroelements including the human endogenous retroviruses (HERVs). ERV3, one of the most studied HERVs, is thought to have integrated 30 to 40 million years ago and is present in higher primates with the exception of gorillas. Taken together, the observation of genome conservation, the detection of transcript expression, and the presence of conserved ORFs is circumstantial evidence for a functional role. A functional role is also suggested by the observation that downregulation of ERV3 is reported in choriocarcinoma. [provided by RefSeq].
Product Categories/Family for anti-ERV3-1 antibody
References
Andersson, A.C., et al. J. Virol. 79(14):9270-9284(2005)
Herve, C.A., et al. Genomics 83(5):940-943(2004)
Blaise, S., et al. Proc. Natl. Acad. Sci. U.S.A. 100(22):13013-13018(2003)
de Parseval, N., et al. J. Virol. 77(19):10414-10422(2003)
Andersson, A.C., et al. Virology 297(2):220-225(2002)
Herve, C.A., et al. Genomics 83(5):940-943(2004)
Blaise, S., et al. Proc. Natl. Acad. Sci. U.S.A. 100(22):13013-13018(2003)
de Parseval, N., et al. J. Virol. 77(19):10414-10422(2003)
Andersson, A.C., et al. Virology 297(2):220-225(2002)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
Calculated MW: 67942
NCBI Official Full Name
endogenous retrovirus group 3 member 1 Env polyprotein
NCBI Official Synonym Full Names
endogenous retrovirus group 3, member 1
NCBI Official Symbol
ERV3-1
NCBI Official Synonym Symbols
ERV3; ERVR; envR; ERV-R; HERVR; HERV-R
NCBI Protein Information
endogenous retrovirus group 3 member 1 Env polyprotein
UniProt Protein Name
Endogenous retrovirus group 3 member 1 Env polyprotein
UniProt Gene Name
ERV3-1
UniProt Synonym Gene Names
ERV3; ERV3 envelope protein; ERV-R envelope protein; SU; TM
UniProt Entry Name
ENR1_HUMAN
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Product Notes
The ERV3-1 erv3-1 (Catalog #AAA28716) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ERV3 Antibody (C-Term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ERV3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry Paraffin (IHC-P), Western Blot (WB). WB~~1:1000 IHC-P~~1:10~50. Researchers should empirically determine the suitability of the ERV3-1 erv3-1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ERV3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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