Rabbit TYMP Polyclonal Antibody | anti-TYMP antibody

TYMP Antibody

Cat. Num. AAA29697

• Gene Names: TYMP; TP; ECGF; ECGF1; MNGIE; MEDPS1; MTDPS1; PDECGF; hPD-ECGF
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: TYMP, Antibody; TYMP Antibody; TYMP; ECGF1; MNGIE; PDECGF; TP; anti-TYMP antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total TYMP protein.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 482

• Applicable Applications for anti-TYMP antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: Western blotting: 1:500 - 1:2000; Immunohistochemistry: 1:50 - 1:100; Immunofluorescence: 1:50 - 1:200
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human TYMP.
• Target Name: TYMP
• Preparation and Storage: Store at -20 degree C

IF (Immunofluorescence)

(Immunofluorescence analysis of HeLa cell using TYMP antibody. Blue: DAPI for nuclear staining.)

IHC (Immunohistochemistry)

(Immunohistochemical analysis of paraffin-embedded human stomach cancer using TYMP antibody at dilution of 1:100 (200x lens).)

IHC (Immunohistochemistry)

(Immunohistochemical analysis of paraffin-embedded human stomach using TYMP antibody at dilution of 1:100 (200x lens).)

IHC (Immunohistochemistry)

(Immunohistochemical analysis of paraffin-embedded human lung cancer using TYMP antibody at dilution of 1:100 (200x lens).)

IHC (Immunohistochemistry)

(Immunohistochemical analysis of paraffin-embedded human kidney cancer using TYMP antibody at dilution of 1:100 (200x lens).)

WB (Western Blot)

(Western blot analysis of extracts of various cell lines, using TYMP antibody.)

Related Product Information for anti-TYMP antibody

Thymidine phosphorylase (TP) is a platelet-derived endothelial cell growth factor (PD-ECGF) that catalyzes the formation of thymine and 2-deoxy-D-ribose-1-phosphate from thymidine and orthophosphate (1). This intracellular enzyme is capable of both promoting angiogenesis and inhibiting apoptosis. Thymidine phosphorylase catalytic activity is required for its angiogenic function (2,3). Increased expression of TP/PD-ECGF is seen in a wide variety of different solid tumors and inflammatory diseases and is often associated with poor prognosis (4,5). Alternatively, TP can activate fluorouracil derivative (DFUR) prodrugs and increase the antitumor activity of the related treatment (1,5). The use of thymidine phosphorylase as a cancer therapeutic target has been studied extensively, with emphasis on either inhibiting TP enzymatic activity or increasing enzyme induction with concomitant DFUR treatment (1,5).

Product Categories/Family for anti-TYMP antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 166158922
• NCBI GeneID: 1890
• NCBI Accession #: NP_001107227.1
• NCBI GenBank Nucleotide #: NM_001113755.2
• UniProt Accession #: P19971; Q13390; Q8WVB7; A8MW15; H9KVA0
• Molecular Weight: 50,405 Da
• NCBI Official Full Name: thymidine phosphorylase isoform 1 proprotein
• NCBI Official Synonym Full Names: thymidine phosphorylase
• NCBI Official Symbol: TYMP
• NCBI Official Synonym Symbols: TP; ECGF; ECGF1; MNGIE; MEDPS1; MTDPS1; PDECGF; hPD-ECGF
• NCBI Protein Information: thymidine phosphorylase
• UniProt Protein Name: Thymidine phosphorylase
• UniProt Gene Name: TYMP
• UniProt Synonym Gene Names: ECGF1; TP; PD-ECGF
• UniProt Entry Name: TYPH_HUMAN