MHC class I chain-related gene B Active Protein | MICB active protein
Recombinant Human MHC class I chain-related gene B
Gene Names
MICB; PERB11.2
Purity
Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Synonyms
MHC class I chain-related gene B; N/A; Recombinant Human MHC class I chain-related gene B; MICB Human; MHC Class-I chain related gene B Human Recombinant; MHC class I polypeptide-related sequence B; MIC-B; MICB; PERB11.2; MICB active protein
Host
E Coli
Purity/Purification
Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Form/Format
Lyophilized from a concentrated (1mg/ml) solution containing no additives.
Sterile Filtered White lyophilized (freeze-dried) powder.
Sterile Filtered White lyophilized (freeze-dried) powder.
Solubility
It is recommended to reconstitute the lyophilized MICB in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Biological Activity
Measured by its ability to bind MICB antibody in ELISA.
Preparation and Storage
Lyophilized MICB although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution MICB should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Related Product Information for MICB active protein
Description: MICB Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 326 amino acids and having a molecular mass of 37kDa. The sequence contains the extracellular domain of the mature human MICB (amino acid residues Ala23 Tyr312). The MICB is purified by proprietary chromatographic techniques.
Introduction: MICB (MHC class I chain-related gene B) is a transmembrane glycoprotein that functions as a ligand for human NKG2D type II receptor. A closely related protein, MICA, shares 85% amino acid identity with MICB. These 2 proteins are distantly related to the MHC class I proteins. MICA and MICB (MICA/B) possess three extracellular immunoglobulin-like domains, but have no capacity to bind peptide or interact with ?2-microglobulin. The genes encoding MICA/B are found within the major histocompatibility complex on human chromosome 6. The MICB locus is polymorphic with more than 15 recognized human alleles. MICA/B are minimally expressed on normal cells, but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MICA/B are ligands for NKG2D, an activating receptor expressed on NK cells, NKT cells, T cells, and CD8+ T cells. Recognition of MICA/B by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. MICA/B recognition is involved in tumor surveillance, viral infections, and autoimmune diseases. The release of soluble forms of MICA/B from tumors down-regulates NKG2D surface expression on effector cells resulting in the impairment of anti-tumor immune response.
Introduction: MICB (MHC class I chain-related gene B) is a transmembrane glycoprotein that functions as a ligand for human NKG2D type II receptor. A closely related protein, MICA, shares 85% amino acid identity with MICB. These 2 proteins are distantly related to the MHC class I proteins. MICA and MICB (MICA/B) possess three extracellular immunoglobulin-like domains, but have no capacity to bind peptide or interact with ?2-microglobulin. The genes encoding MICA/B are found within the major histocompatibility complex on human chromosome 6. The MICB locus is polymorphic with more than 15 recognized human alleles. MICA/B are minimally expressed on normal cells, but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MICA/B are ligands for NKG2D, an activating receptor expressed on NK cells, NKT cells, T cells, and CD8+ T cells. Recognition of MICA/B by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. MICA/B recognition is involved in tumor surveillance, viral infections, and autoimmune diseases. The release of soluble forms of MICA/B from tumors down-regulates NKG2D surface expression on effector cells resulting in the impairment of anti-tumor immune response.
Product Categories/Family for MICB active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
4,287 Da
NCBI Official Full Name
MHC class I polypeptide-related sequence B isoform 2
NCBI Official Synonym Full Names
MHC class I polypeptide-related sequence B
NCBI Official Symbol
MICB
NCBI Official Synonym Symbols
PERB11.2
NCBI Protein Information
MHC class I polypeptide-related sequence B; MHC class I chain-related protein B; MHC class I mic-B antigen; MHC class I-like molecule PERB11.2-IMX; MICB; stress inducible class I homolog
UniProt Protein Name
MHC class I polypeptide-related sequence B
UniProt Gene Name
MICB
UniProt Synonym Gene Names
MIC-B
UniProt Entry Name
MICB_HUMAN
