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IHC (Immunohistchemistry)
(CTNNB1/Beta Catenin Antibody-Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit anti-Human CTNNB1/Beta Catenin Polyclonal Antibody | anti-CTNNB1 antibody
CTNNB1/Beta Catenin Rabbit anti-Human Polyclonal Antibody
Gene Names
CTNNB1; CTNNB; MRD19; armadillo
Reactivity
Human
Applications
Immunohistochemistry, Western Blot
Purity
Immunoaffinity purified
Synonyms
CTNNB1/Beta Catenin, Antibody; CTNNB1/Beta Catenin Rabbit anti-Human Polyclonal Antibody; PathPlus CTNNB1/Beta Catenin Antibody; CTNNB1; Beta-catenin; Catenin beta-1; CTNNB; Beta Catenin; anti-CTNNB1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, 0.1% Sodium Azide
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-CTNNB1 antibody
Immunohistochemistry-Paraffin (IHC-P), Simple Western Blot (SWB)
Target
Human CTNNB1/Beta Catenin
Immunogen
LP-10841, synthetic peptide
Conjugation
Unconjugated
Family
Catenin
Preparation and Storage
Aliquot and store undiluted at -20 degree C or below for up to 1 year. Can be stored undiluted at 4 degree C for up to 1 month. Avoid freeze-thaw cycles.
IHC (Immunohistchemistry)
(CTNNB1/Beta Catenin Antibody-Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistchemistry)
(CTNNB1/Beta Catenin Antibody-Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(CTNNB1/Beta Catenin Antibody-Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(CTNNB1/Beta Catenin Antibody-Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(CTNNB1/Beta Catenin Antibody-Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(CTNNB1/Beta Catenin Antibody-Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(CTNNB1/Beta Catenin Antibody-Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(CTNNB1/Beta Catenin Antibody-Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(CTNNB1/Beta Catenin Antibody-Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(CTNNB1/Beta Catenin Antibody-Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE))
WB (Western Blot)
(CTNNB1/Beta Catenin Antibody-Anti-CTNNB1 antibody (AAA21342, 20 ug/mL) yields a specific band on capillary Western analysis (Protein Simple, WES, 12-230 kDa separation module) in 0.25 mg/mL human beta-catenin overexpression lysate.)
WB (Western Blot)
(CTNNB1/Beta Catenin Antibody-Anti-CTNNB1 antibody (AAA21342, 20 ug/mL) yields a specific band on capillary Western analysis (Protein Simple, WES, 12-230 kDa separation module) in 0.25 mg/mL human beta-catenin overexpression lysate.)
Related Product Information for anti-CTNNB1 antibody
Beta Catenin antibody is an unconjugated rabbit polyclonal antibody to Beta Catenin (CTNNB1) from human. Validated for IHC and SWB.
Beta-Catenin (CTNNB1) is a member of the armadillo family of proteins, and part of the Wnt/beta-catenin signaling pathway. It binds to the cytoplasmic region of the e-cadherin molecule (part of the adherens junction), a complex that is necessary for the creation and maintenance of epithelial layers by regulating cell growth and adhesion, as well as anchoring the actin cytoskeleton. This protein also binds to the APC gene, and mutations in this gene are implicated in colon cancer, papillary thyroid cancer, pilomatrixoma, medulloblastoma, and ovarian cancer. In pathology, CTNNB1 is used to identify desmoid tumors, colorectal cancer, and colon adenomas. It is positive in the membrane of the epithelium of the colon and appendix, weak in endothelial cells, hepatocytes, satellite cells in nerves and follicular dendritic cells in lymph nodes. Staining is membranous in normal colon, and can become nuclear in adenomas and adenocarcinomas.
Beta-Catenin (CTNNB1) is a member of the armadillo family of proteins, and part of the Wnt/beta-catenin signaling pathway. It binds to the cytoplasmic region of the e-cadherin molecule (part of the adherens junction), a complex that is necessary for the creation and maintenance of epithelial layers by regulating cell growth and adhesion, as well as anchoring the actin cytoskeleton. This protein also binds to the APC gene, and mutations in this gene are implicated in colon cancer, papillary thyroid cancer, pilomatrixoma, medulloblastoma, and ovarian cancer. In pathology, CTNNB1 is used to identify desmoid tumors, colorectal cancer, and colon adenomas. It is positive in the membrane of the epithelium of the colon and appendix, weak in endothelial cells, hepatocytes, satellite cells in nerves and follicular dendritic cells in lymph nodes. Staining is membranous in normal colon, and can become nuclear in adenomas and adenocarcinomas.
References
Prakash, J Oral Maxillofac Pathol 2015 19(2):230; Luu 2004, Curr Cancer Drug Targets 4(8):653.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
9,501 Da
NCBI Official Full Name
catenin beta-1
NCBI Official Synonym Full Names
catenin (cadherin-associated protein), beta 1, 88kDa
NCBI Official Symbol
CTNNB1
NCBI Official Synonym Symbols
CTNNB; MRD19; armadillo
NCBI Protein Information
catenin beta-1
UniProt Protein Name
Catenin beta-1
UniProt Gene Name
CTNNB1
UniProt Synonym Gene Names
CTNNB
UniProt Entry Name
CTNB1_HUMAN
Similar Products
Product Notes
The CTNNB1 ctnnb1 (Catalog #AAA21342) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CTNNB1/Beta Catenin Rabbit anti-Human Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CTNNB1/Beta Catenin can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P), Simple Western Blot (SWB). Researchers should empirically determine the suitability of the CTNNB1 ctnnb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CTNNB1/Beta Catenin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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