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Application Data
(Analysis of Protein Array containing >19, 000 full-length human proteins using TACSTD2 Mouse Monoclonal Antibody (TACSTD2/2153) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
Mouse TACSTD2/TROP2 Monoclonal Antibody | anti-TACSTD2 antibody
TACSTD2/TROP2 (Epithelial Marker)
Gene Names
TACSTD2; EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1
Reactivity
Human. Others not known.
Applications
Immunohistochemistry
Synonyms
TACSTD2/TROP2, Antibody; TACSTD2/TROP2 (Epithelial Marker); Cell surface glycoprotein Trop-2; Membrane Component Chromosome 1, Surface Marker 1 (M1S1); Pancreatic Carcinoma Marker Protein GA733-1; TROP2; Tumor-Associated Calcium Signal Transducer 2 (TACSTD2); anti-TACSTD2 antibody
Host
Mouse
Reactivity
Human. Others not known.
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
TACSTD2/2153
Specificity
TACSTD2is a cell surface glycoprotein receptor. It is a single pass type I membrane protein containing one thyroglobulin type-1 domain, an epidermal growth factor-like repeat, a phosphatidylinositol binding site and tyrosine phosphorylation sites near the C-terminus. It plays a role intransducing intracellular calcium signals. It is expressed in trophoblast cells, cornea and multi-stratified epithelia. It is also highly expressed in several types of tumors and is involved in regulating the growth of carcinoma cells.
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Sequence Length
323
Applicable Applications for anti-TACSTD2 antibody
Immunohistochemistry (IHC) Formalin
Application Notes
IHC-F: 1-2ug/ml for 30 min at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes
Immunogen
Recombinant fragment of human TACSTD2 protein (around aa 31-274)
Cellular Localization
Cell Surface
Hu-chromosome Location
1p32.1
Positive Control
HT29 cells. Breast or Colon Carcinoma
Application Data
(Analysis of Protein Array containing >19, 000 full-length human proteins using TACSTD2 Mouse Monoclonal Antibody (TACSTD2/2153) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
Application Data
(Analysis of Protein Array containing >19, 000 full-length human proteins using TACSTD2 Mouse Monoclonal Antibody (TACSTD2/2153) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
SDS-PAGE
(SDS-PAGE Analysis Purified TACSTD2 / TROP2Mouse Monoclonal Antibody (TACSTD2/2153).Confirmation of Integrity and Purity of Antibody.)
SDS-PAGE
(SDS-PAGE Analysis Purified TACSTD2 / TROP2Mouse Monoclonal Antibody (TACSTD2/2153).Confirmation of Integrity and Purity of Antibody.)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embeddedhuman PancreaticCarcinoma stained with TACSTD2 / TROP2Mouse Monoclonal Antibody (TACSTD2/2153).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embeddedhuman PancreaticCarcinoma stained with TACSTD2 / TROP2Mouse Monoclonal Antibody (TACSTD2/2153).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embeddedhuman PancreaticCarcinoma stained with TACSTD2 / TROP2Mouse Monoclonal Antibody (TACSTD2/2153).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embeddedhuman PancreaticCarcinoma stained with TACSTD2 / TROP2Mouse Monoclonal Antibody (TACSTD2/2153).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embeddedhuman Basal Cell Carcinoma stained with TACSTD2 / TROP2Mouse Monoclonal Antibody (TACSTD2/2153).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embeddedhuman Basal Cell Carcinoma stained with TACSTD2 / TROP2Mouse Monoclonal Antibody (TACSTD2/2153).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embeddedhuman Colon Carcinoma stained with TACSTD2 / TROP2Mouse Monoclonal Antibody (TACSTD2/2153).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embeddedhuman Colon Carcinoma stained with TACSTD2 / TROP2Mouse Monoclonal Antibody (TACSTD2/2153).)
References
Fornaro, M., et al. 1995. Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas. Int. J. Cancer 62: 610-618.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
40kDa
NCBI Official Full Name
tumor-associated calcium signal transducer 2
NCBI Official Synonym Full Names
tumor associated calcium signal transducer 2
NCBI Official Symbol
TACSTD2
NCBI Official Synonym Symbols
EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1
NCBI Protein Information
tumor-associated calcium signal transducer 2
UniProt Protein Name
Tumor-associated calcium signal transducer 2
UniProt Gene Name
TACSTD2
UniProt Synonym Gene Names
GA733-1; M1S1; TROP2
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Product Notes
The TACSTD2 tacstd2 (Catalog #AAA23900) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The TACSTD2/TROP2 (Epithelial Marker) reacts with Human. Others not known. and may cross-react with other species as described in the data sheet. AAA Biotech's TACSTD2/TROP2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Formalin. IHC-F: 1-2ug/ml for 30 min at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes. Researchers should empirically determine the suitability of the TACSTD2 tacstd2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TACSTD2/TROP2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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