Application Data
ACVR2A recombinant protein
Recombinant Mouse ACVR2A Protein (mFc Tag), HPLC-verified
Gene Names
Acvr2a; Acvr2; ActrIIa; TactrII
Reactivity
Mouse
Purity
>= 90% as determined by SDS-PAGE. >= 95% as determined by SEC-HPLC.
Synonyms
ACVR2A; N/A; Recombinant Mouse ACVR2A Protein (mFc Tag), HPLC-verified; Mouse ACVR2A Protein (mFc Tag); activin A receptor, type IIA; ActrIIa Protein, Mouse; Acvr2 Protein, Mouse; Acvr2a Protein, Mouse; TactrII Protein, Mouse; ACVR2A recombinant protein
Host
HEK293 Cells
Reactivity
Mouse
Purity/Purification
>= 90% as determined by SDS-PAGE. >= 95% as determined by SEC-HPLC.
Form/Format
Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Sequence
Met1-Pro134
Tag
C-mouse IgG2a-Fc
Predicted N Terminal
Ala 20
Endotoxin
< 1.0 EU perug of the protein as determined by the LAL method
Protein Construction
A DNA sequence encoding the Mouse ACVR2A (P27038)(Met1-Pro134) was expressed with the Fc region of mouse IgG2a at the C-terminus.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Application Data
Application Data
Application Data
Application Data
Related Product Information for ACVR2A recombinant protein
ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein of 513 amino acids which is highly homologous (approximately 98% identity) to the rat, mouse, and human ACVR2A proteins. Inactivation of ACVR2A is a common event in prostate cancer cells suggesting it may play an important role in the development of prostate cancer. The ACVR2A gene is a putative tumor suppressor gene that is frequently mutated in microsatellite-unstable colon cancers (MSI-H colon cancers). Frameshift mutation of ACVR2A may contribute to MSI-H colon tumorigenesis via disruption of alternate TGF-beta effector pathways.
References
Albertso. RC. e. al. (2005. Zebrafis. acvr2. an. acvr2. exhibi. distinc. role. i. craniofacia. development. Developmenta. dynamic. 233(4). 1405-18.Chun. H. e. al. (2008. Mutatio. rate. o. TGFBR. an. ACVR. codin. microsatellite. i. huma. cell. wit. defectiv. DN. mismatc. repair. Plo. on. 3(10). e3463.Fitzpatric. E. e. al. (2009. Geneti. associatio. o. th. activi. . recepto. gen. (ACVR2A. an. pre-eclampsia. Molecula. huma. reproductio. 15(3):195-204.Rote. LT. e. al. (2009. Associatio. betwee. th. candidat. susceptibilit. gen. ACVR2. o. chromosom. 2q2. an. pre-eclampsi. i. . larg. Norwegia. population-base. stud. (th. HUN. study). EJHG. 17(2). 250-7.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
57,890 Da
NCBI Official Full Name
activin receptor type-2A
NCBI Official Synonym Full Names
activin receptor IIA
NCBI Official Symbol
Acvr2a
NCBI Official Synonym Symbols
Acvr2; ActrIIa; TactrII
NCBI Protein Information
activin receptor type-2A
UniProt Protein Name
Activin receptor type-2A
UniProt Gene Name
Acvr2a
UniProt Synonym Gene Names
Acvr2; ACTR-IIA
UniProt Entry Name
AVR2A_MOUSE
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Product Notes
The ACVR2A acvr2a (Catalog #AAA259313) is a Recombinant Protein produced from HEK293 Cells and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Mouse ACVR2A Protein (mFc Tag), HPLC-verified reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: Met1-Pro13 4. It is sometimes possible for the material contained within the vial of "ACVR2A, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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