Application Data
Nigericin Antibiotic
Nigericin
Synonyms
Nigericin; N/A; Nigericin antibiotic
Sequence Length
145
NOTE
• Danger! Nigericin is toxic if swallowed, causes skin irritation, causes serious eye irritation, and may cause respiratory irritation.
Preparation and Storage
Store at <-20°C.
Upon reconstitution in DMSO, store at -20°C.
Reconstituted Nigericin is stable up to 1 year at -20°C.
Upon reconstitution in DMSO, store at -20°C.
Reconstituted Nigericin is stable up to 1 year at -20°C.
Application Data
Application Data
Application Data
(Hazard Safety)
Application Data
(Hazard Safety)
Related Product Information for Nigericin antibiotic
INTRODUCTION: Activation of the NLRP3 inflammasome in myeloid cells follows exposure to pathogen-associated molecular patterns (first signal) and ATP (second signal). This leads to oligomerization and assembly of a high molecular weight (~700 kDa) multimeric inflammasome complex, which leads to the conversion of pro-caspase-1 into the catalytically active form. Inflammatory caspases, such as caspase-1, or interleukin-converting enzyme (ICE), play a central role in innate immunity by recognizing cytosolic foreign danger signals and initiating a two-fold response. First, caspase-1 proteolytically converts the proforms of the two important pro-inflammatory cytokines, interleukin-1ß (IL-1ß) and interleukin-18 (IL-18), into their active forms, which are secreted. Second, caspase-1 or caspase-11 triggers a form of lytic, programmed cell death known as pyroptosis. Nigericin is a potent microbial toxin derived from Streptomyces hygroscopicus. It acts as a potassium ionophore, inducing a net decrease in intracellular levels of potassium, which is crucial for oligomerization of the NLRP3 inflammasome and activation of caspase-1. Nigericin requires signaling through pannexin-1 to induce caspase-1 activation and IL-1ß processing and release. It has been shown to generate a robust caspase-1 activation response in various cell lines, including Jurkat and THP-I cells.
Product Categories/Family for Nigericin antibiotic
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
746.94 g/mol
NCBI Official Full Name
nigBI epoxide hydrolase involved in nigericin biosynthesis
Similar Products
Product Notes
The Nigericin (Catalog #AAA52750) is an Antibiotic and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Nigericin, Antibiotic" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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