Application Data
APLP2 recombinant protein
Recombinant Human APLP2 Protein (ECD, His Tag), HPLC-verified
Gene Names
APLP2; APPH; APPL2; CDEBP; APLP-2
Reactivity
Human
Purity
>= 90% as determined by SDS-PAGE. >= 95% as determined by SEC-HPLC.
Synonyms
APLP2; N/A; Recombinant Human APLP2 Protein (ECD, His Tag), HPLC-verified; Human APLP2 Protein (ECD, His Tag); amyloid beta precursor like protein 2; APLP-2 Protein, Human; APPH Protein, Human; APPL2 Protein, Human; CDEBP Protein, Human; APLP2 recombinant protein
Host
HEK293 Cells
Reactivity
Human
Purity/Purification
>= 90% as determined by SDS-PAGE. >= 95% as determined by SEC-HPLC.
Form/Format
Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Sequence
Met1-Ser692
Tag
C-His
Predicted N Terminal
Gly 32
Endotoxin
< 1.0 EU perug of the protein as determined by the LAL method
Protein Construction
A DNA sequence encoding the Human APLP2 (Q06481-1)(Met1-Ser692) was expressed with a polyhistidine tag at the C-terminus.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Application Data
Application Data
Application Data
Application Data
Related Product Information for APLP2 recombinant protein
YWK-II protein/APLP2 is a member of an evolutionarily conserved APP family that includes amyloid precursor protein (APP) and amyloid precursor-like protein-1 (APLP1). YWK-II/APLP2 functions as a novel G(0)-protein-coupled receptor for Müllerian inhibiting substance (MIS) in cell survival. Human leukocyte antigen-B-associated transcript 3 (Bat3), an important regulator involved in apoptosis, can interact with YWK-II/APLP2 and enhance its stability by reducing its ubiquitylation and degradation by the ubiquitin-proteasome system. APLP2 is specifically required for proper cell cycle exit of neuronal progenitors, and has a distinct role in priming cortical progenitors for neuronal differentiation. Amyloid precursor like protein-2 (APLP2), a closely related homolog to AbetaPP, also possesses a highly conserved KPI domain. AbetaPP and APLP2 share overlapping anticoagulant functions with regard to regulating thrombosis after cerebral vascular injury.
References
Wan. X. e. al. (2018. Aplp. modulate. jnk-dependen. cel. migratio. i. drosophila. Biome. Re. In. 201. 7469714.Ha. K. e. al. (2017. Amyloid-precurso. lik. protein. aplp. an. aplp. ar. dispensabl. fo. norma. developmen. o. th. neonata. respirator. network. Fron. Mo. Neurosc. 1. 189.Ga. L. e. al. (2019. Rol. o. aplp. i. th. prognosi. an. clinicopatholog. o. rena. cel. carcinoma. Onco. Let. 1. (1). 508-513.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
86,956 Da
NCBI Official Full Name
amyloid-like protein 2 isoform 2
NCBI Official Synonym Full Names
amyloid beta (A4) precursor-like protein 2
NCBI Official Symbol
APLP2
NCBI Official Synonym Symbols
APPH; APPL2; CDEBP; APLP-2
NCBI Protein Information
amyloid-like protein 2; CDEI box-binding protein; amyloid precursor protein homolog HSD-2
UniProt Protein Name
Amyloid-like protein 2
UniProt Gene Name
APLP2
UniProt Synonym Gene Names
APPL2; APLP-2; CDEBP
UniProt Entry Name
APLP2_HUMAN
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Product Notes
The APLP2 aplp2 (Catalog #AAA259328) is a Recombinant Protein produced from HEK293 Cells and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Human APLP2 Protein (ECD, His Tag), HPLC-verified reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: Met1-Ser69 2. It is sometimes possible for the material contained within the vial of "APLP2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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