aCella - Tox - an designed to measure cell cytoxicity Assay Kit
aCella - Tox - an assay designed to measure cell cytoxicity
Synonyms
aCella - Tox - an designed to measure cell cytoxicity; N/A; aCella - Tox - an assay designed to measure cell cytoxicity; aCella - TOX 500 Tests; aCella - Tox - an designed to measure cell cytoxicity assay kit
Method of Analysis
Luminometer
Preparation and Storage
Store contents as labeled
Shipping: Blue Ice/Gel Packs
Shipping: Blue Ice/Gel Packs
Related Product Information for aCella - Tox - an designed to measure cell cytoxicity assay kit
Principle of the Assay: A bioluminescence, non-radioactive cytotoxicity assay designed to quantitatively measure the release of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from mammalian cell lines or bacterial cells.
Product Categories/Family for aCella - Tox - an designed to measure cell cytoxicity assay kit
References
Overholser, J., et al. 2015. Anti-tumor effects of peptide therapeutic and peptide vaccine antibody co-targeting HER-1 and HER-2 in esophageal cancer (EC) and HER-1 and IGF-1R in triple …. Vaccines (Basel), 519-43.
Sano, R., et al. 2019. An antibody-drug conjugate directed to the ALK receptor demonstrates efficacy in preclinical models of neuroblastoma. Science Translational Medicine, eaau9732.
Riss, T., et al. 2019. Cytotoxicity assays: in vitro methods to measure dead cells. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences, .
Sanabria-Figueroa, E., et al. 2015. Insulin-like growth factor-1 receptor signaling increases the invasive potential of human epidermal growth factor receptor 2-overexpressing breast cancer cells via Src-focal adhesion kinase and forkhead box protein M1. Molecular Pharmacology , 150-61.
Simhadri, V.R., et al. 2015. A Human Anti-M2 Antibody Mediates Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) and Cytokine Secretion by Resting and Cytokine-Preactivated Natural Killer (NK) Cells. PLoS One, e0124677.
Bekaii-Saab, T.., et al. 2019. Phase I Immunotherapy Trial with Two Chimeric HER-2 B-Cell Peptide Vaccines Emulsified in Montanide ISA 720VG and Nor-MDP Adjuvant in Patients with Advanced Solid Tumors. Clinical Trial Clin Cancer Res, 3495-3507.
Tsuji, W., et al. 2015. Effects of immunosuppressive drugs on viability and susceptibility of adipose-and bone marrow-derived mesenchymal stem cells. Frontiers in Immunology, 131.
Fisher, T.L., et al. 2016. Generation and preclinical characterization of an antibody specific for SEMA4D. Mabs, 150-62.
Liu, J., et al. 2015. Pre-clinical development of a humanized anti-CD47 antibody with anti-cancer therapeutic potential. PLoS One, e0137345.
Lewis, C.S., et al. 2021. A First-In-Class, Humanized Antibody Targeting Alternatively Spliced Tissue Factor: Preclinical Evaluation in an Orthotopic Model of Pancreatic Ductal Adenocarcinoma. Frontiers in Oncology, 691685.
Guo, L., et al. 2022. A newly discovered PD-L1 B-cell epitope peptide vaccine (PDL1-Vaxx) exhibits potent immune responses and effective anti-tumor immunity in multiple syngeneic mice models and (synergizes) in combination with a dual HER-2 B-cell vaccine (B-Vaxx). Oncoimmunology, 2127691.
Zhukovskaya, N.L., et al. 2015. The processivity factor complex of feline herpes virus-1 is a new drug target. Antiviral Research, 17-20.
Zecca, A., et al. 2020. Energy metabolism and cell motility defect in NK-cells from patients with hepatocellular carcinoma. Cancer Immunology, Immunotherapy, 1589-1603.
Láng, J.A., et al. 2020. In vitro functional characterization of biosimilar therapeutic antibodies. Drug Discovery Today: Technologies, 41-50.
A mathematical model of antibody-dependent cellular cytotoxicity (ADCC). Journal of Theoretical Biology, 39-50.
Dash, R., et al. 2022. Assessment of Functional Characterization and Comparability of Biotherapeutics: a Review. AAPS Journal, 15.
Sano, R., et al. 2019. An antibody-drug conjugate directed to the ALK receptor demonstrates efficacy in preclinical models of neuroblastoma. Science Translational Medicine, eaau9732.
Riss, T., et al. 2019. Cytotoxicity assays: in vitro methods to measure dead cells. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences, .
Sanabria-Figueroa, E., et al. 2015. Insulin-like growth factor-1 receptor signaling increases the invasive potential of human epidermal growth factor receptor 2-overexpressing breast cancer cells via Src-focal adhesion kinase and forkhead box protein M1. Molecular Pharmacology , 150-61.
Simhadri, V.R., et al. 2015. A Human Anti-M2 Antibody Mediates Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) and Cytokine Secretion by Resting and Cytokine-Preactivated Natural Killer (NK) Cells. PLoS One, e0124677.
Bekaii-Saab, T.., et al. 2019. Phase I Immunotherapy Trial with Two Chimeric HER-2 B-Cell Peptide Vaccines Emulsified in Montanide ISA 720VG and Nor-MDP Adjuvant in Patients with Advanced Solid Tumors. Clinical Trial Clin Cancer Res, 3495-3507.
Tsuji, W., et al. 2015. Effects of immunosuppressive drugs on viability and susceptibility of adipose-and bone marrow-derived mesenchymal stem cells. Frontiers in Immunology, 131.
Fisher, T.L., et al. 2016. Generation and preclinical characterization of an antibody specific for SEMA4D. Mabs, 150-62.
Liu, J., et al. 2015. Pre-clinical development of a humanized anti-CD47 antibody with anti-cancer therapeutic potential. PLoS One, e0137345.
Lewis, C.S., et al. 2021. A First-In-Class, Humanized Antibody Targeting Alternatively Spliced Tissue Factor: Preclinical Evaluation in an Orthotopic Model of Pancreatic Ductal Adenocarcinoma. Frontiers in Oncology, 691685.
Guo, L., et al. 2022. A newly discovered PD-L1 B-cell epitope peptide vaccine (PDL1-Vaxx) exhibits potent immune responses and effective anti-tumor immunity in multiple syngeneic mice models and (synergizes) in combination with a dual HER-2 B-cell vaccine (B-Vaxx). Oncoimmunology, 2127691.
Zhukovskaya, N.L., et al. 2015. The processivity factor complex of feline herpes virus-1 is a new drug target. Antiviral Research, 17-20.
Zecca, A., et al. 2020. Energy metabolism and cell motility defect in NK-cells from patients with hepatocellular carcinoma. Cancer Immunology, Immunotherapy, 1589-1603.
Láng, J.A., et al. 2020. In vitro functional characterization of biosimilar therapeutic antibodies. Drug Discovery Today: Technologies, 41-50.
A mathematical model of antibody-dependent cellular cytotoxicity (ADCC). Journal of Theoretical Biology, 39-50.
Dash, R., et al. 2022. Assessment of Functional Characterization and Comparability of Biotherapeutics: a Review. AAPS Journal, 15.
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Product Notes
The aCella - Tox - an designed to measure cell cytoxicity (Catalog #AAA52777) is an Assay Kit and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "aCella - Tox - an designed to measure cell cytoxicity, Assay Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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