SDS-PAGE
(3ug by SDS-PAGE under reducing condtion and visualized by coomassie blue stain)
Ataxin 3 Recombinant Protein | ATXN3 recombinant protein
Ataxin 3, 1-370aa, Human, E Coli
Gene Names
ATXN3; AT3; JOS; MJD; ATX3; MJD1; SCA3
Applications
SDS-Page
Purity
> 90% by SDS-PAGE
Synonyms
Ataxin 3; N/A; Ataxin 3, 1-370aa, Human, E Coli; ATX3; MJD; MJD1; SCA3; ATXN3; JOS; AT3; EC 3.4.22.; Josephin; Machado Joseph disease; Machado Joseph disease protein 1; Machado-Joseph disease protein 1 homolog; MJD gene; Rsca3; SCA3 gene; Spinocerebellar ataxia type 3 protein,; ATXN3 recombinant protein
Host
E Coli
Purity/Purification
> 90% by SDS-PAGE
Form/Format
Liquid. In 20 mM Tris-HCl Buffer (pH 7.5) containing 2mM DTT, 50mM NaCl, 10% glycerol.
Concentration
1 mg/ml (determined by Bradford assay) (varies by lot)
Sequence Length
370
Applicable Applications for ATXN3 recombinant protein
SDS-PAGE
Antigen Species
Human
Tag
Non-tagged
Endotoxin Level
< 1.0 EU per 1 microgram of protein (determined by LAL method)
Preparation and Storage
Can be stored 2-8°C for 1 week. For long term storage aliquot and store at -20°C to -80°C. Avoid freeze thaw cycles.
SDS-PAGE
(3ug by SDS-PAGE under reducing condtion and visualized by coomassie blue stain)
SDS-PAGE
(3ug by SDS-PAGE under reducing condtion and visualized by coomassie blue stain)
Related Product Information for ATXN3 recombinant protein
Ataxin 3 is also known as Machado-Joseph disease protein 1. Machado-Joseph disease is one of several hereditary autosomal dominant neurodegenerative disorders. This protein contains trinucleotide CAG repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. Ataxin 3 interacts with the major histone acetyltransferases cAMP-response-element binding protein (CREB)-binding protein, p300, and p300/CREB-binding protein-associated factor and inhibits transcription by these coactivators. Also, ataxin-3 is a proteasome-associated factor that mediates the degradation of ubiquitinated proteins. Recombinant human Ataxin-3 was expressed in E Coli and purified by using conventional chromatography.
Product Categories/Family for ATXN3 recombinant protein
References
Doss Pepe EW., et al. (2003). Mol Cell Biol. 23 (18):6469-83. ; Paulson., et al. (1997). Ann Neurol. 41 (4):453-62.;
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
42.4 kDa (370aa), confirmed by MALDI-TOF.
NCBI Official Full Name
ATXN3 protein
NCBI Official Synonym Full Names
ataxin 3
NCBI Official Symbol
ATXN3
NCBI Official Synonym Symbols
AT3; JOS; MJD; ATX3; MJD1; SCA3
NCBI Protein Information
ataxin-3
UniProt Protein Name
Ataxin-3
UniProt Gene Name
ATXN3
UniProt Synonym Gene Names
ATX3; MJD; MJD1; SCA3
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Product Notes
The ATXN3 atxn3 (Catalog #AAA48544) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Ataxin 3 can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE. Researchers should empirically determine the suitability of the ATXN3 atxn3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Ataxin 3, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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