Structure
(Biotin-PEG1-NH2, CAS 811442-85-0)
3-Methylthienyl-carbonyl-JNJ-7706621 Biochemical
3-Methylthienyl-carbonyl-JNJ-7706621
Purity
98%
Synonyms
3-Methylthienyl-carbonyl-JNJ-7706621; N/A; 3-Methylthienyl-carbonyl-JNJ-7706621 biochemical
Purity/Purification
98%
CAS
443798-09-2
Targets&IC50
CDK4:0.11 uM (IC50), GSK3:41 nM (IC50), CDK2/CyclinA:2 nM (IC50), FGFR2:0.22 uM (IC50), CDK1/CyclinB:6.4 nM (IC50), VEGFR2:0.13 uM (IC50)
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
3-Methylthienyl-carbonyl-JNJ-7706621 (75-125 mg/kg; i.p. once daily for 32 days) inhibits the A375 human melanoma tumor growth and prolongs the survival in nude mice[1]. 3-Methylthienyl-carbonyl-JNJ-7706621 exhibits oral bioavailability (nude mouse 2%, rat 8%, dog 63.3%), terminal elimination half-lives (nude mouse 1.70, rat 2.20 and, dog 2.36 h) and C max (nude mouse 0.21, rat 2.5, dog 4.58 uM) following oral administration (nude mouse 30, rat 30, dog 10 mg/kg)[1]. 3-Methylthienyl-carbonyl-JNJ-7706621 exhibits terminal elimination half-lives (nude mouse 0.51, rat 0.64 and, dog 3.89 h), C max (nude mouse 6.4, rat 23.2, dog 2.19 uM) and AUC (nude mouse 3.2, rat 11.4, dog 2.45 uM/h) following intravenous administration (nude mouse 3, rat 3 and, dog 1 mg/kg)[1]. Animal Model: Male athymic mice were implanted with A375 human melanoma cells[1]. Dosage: 75, 100, 125 mg/kg. Administration: I.p. once daily for 32 days. Result: Reduced the tumor growth. Survival was increased by about 3 weeks compared with vector alone.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Biotin-PEG1-NH2, CAS 811442-85-0)
Structure
(Biotin-PEG1-NH2, CAS 811442-85-0)
Structure
(Biotin-PEG1-NH2, CAS 811442-85-0)
Structure
(Biotin-PEG1-NH2, CAS 811442-85-0)
Related Product Information for 3-Methylthienyl-carbonyl-JNJ-7706621 biochemical
3-Methylthienyl-carbonyl-JNJ-7706621 is a potent and selective inhibitor of cyclin-dependent kinase (CDK), with IC 50 s of 6.4 nM and 2 nM for CDK1/cyclin B and CDK2/cyclin A, respectively. 3-Methylthienyl-carbonyl-JNJ-7706621 also shows potent inhibition of GSK-3 (IC 50 =0.041 uM) and modest potency against CDK4, VEGF-R2, and FGF-R2 (IC 50 =0.11, 0.13, 0.22 uM, respectively). 3-Methylthienyl-carbonyl-JNJ-7706621 can be used for the research of cancer.
References
1. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
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Product Notes
The 3-Methylthienyl-carbonyl-JNJ-7706621 (Catalog #AAA228717) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "3-Methylthienyl-carbonyl-JNJ-7706621, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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