Application Data
8- Bromoadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer (Sp-8-Br-cAMPS) Biochemical
8- Bromoadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer (Sp-8-Br-cAMPS)
Purity
Typical analysis is better than 98% (HPLC / UV / 264 nm).The product is not sterile and has not been tested for endotoxins.
Synonyms
8- Bromoadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer (Sp-8-Br-cAMPS); N/A; 8- Bromoadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer (Sp-8-Br-cAMPS) biochemical
Specificity
Lyophilized or crystallized sodium salt. The free acid or other salt forms are available upon request. Equal concentrations of Sp-8-Br-cAMPS can appear very different in volume due to sensitivity of the lyophilized form to humidity. The compound can even contract to small volume droplets. Normally the compound is located in the conical bottom of the tube. Micromolar quantities are determined by UV at λmax
Purity/Purification
Typical analysis is better than 98% (HPLC / UV / 264 nm).
The product is not sterile and has not been tested for endotoxins.
The product is not sterile and has not been tested for endotoxins.
Unit Equivalent
5 umol is approximately equals to 2.2 mg
CAS No.
127634-20-2
Formula
C10H10BrN5O5PS.Na
Properties
Sp-8-Br-cAMPS combines the structures of the two well known protein kinase activators Sp-cAMPS and 8-Br-cAMP yielding a novel membrane permeant cyclic AMP mimetic 1 - 5, 6, 7 which is not degraded by mammalian cyclic nucleotide phosphodiesterases. Sp-8-Br-cAMPS is about 2 times more lipophilic compared to 8-Br-cAMP and Sp-cAMPS and 4 times more compared to cAMP, respectively 8. If you have good or moderate results with 8-Br-cAMP or Sp-cAMPS, you can be sure that Sp-8-Br-cAMPS will be membrane-permeant in your system as well.
Solubility
Detailed information on the solubility of Sp-8-Br-cAMPS in water and various buffers are listed in the solubility chart below.
Concentrations have been tested at ambient temperature and can be considered as minimum concentrations usually obtainable, however, slight batch-to-batch variations cannot be ruled out. When opening the tube please make sure that no substance is lost within the cap. Please rinse tube walls carefully and preferably use ultrasonic or vortex to achieve total and uniform mixing.
Concentrations have been tested at ambient temperature and can be considered as minimum concentrations usually obtainable, however, slight batch-to-batch variations cannot be ruled out. When opening the tube please make sure that no substance is lost within the cap. Please rinse tube walls carefully and preferably use ultrasonic or vortex to achieve total and uniform mixing.
Preparation and Storage
Sp-8-Br-cAMPS has sufficient stability at room temperature and does not need special care during handling. Nevertheless, we recommend that the compound should be stored in the freezer, for longer storage periods preferably in
freeze-dried form.
Application Data
Application Data
Structure
Structure
Related Product Information for 8- Bromoadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer (Sp-8-Br-cAMPS) biochemical
Description: Sp-8-Br-cAMPS is an analogue of the parent compound cyclic AMP in which the hydrogen in position 8 of the nucleobase is replaced by bromine and the axial one of the two exocyclic oxygen atoms in the cyclic phosphate moiety is modified by sulfur. The suffix "p" indicates that R/S nomenclature refers to phosphorus.
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Product Notes
The 8- Bromoadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer (Sp-8-Br-cAMPS) (Catalog #AAA52699) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "8- Bromoadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer (Sp-8-Br-cAMPS), Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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