Structure
(Chk1-IN-6, CAS 2428423-77-0)
AKR1B10-IN-1 biochemical
AKR1B10-IN-1
Purity
98%
Synonyms
AKR1B10-IN-1; N/A; AKR1B10-IN-1 biochemical
Purity/Purification
98%
CAS
2136579-33-2
Targets&IC50
AKR1B10:3.5 nM, AKR1B1:277 nM
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
AKR1B10-IN-1 (compound 4e)(0-20 uM; 96 hours) dose-dependently suppresses the growth of both A549 and A549/1B10 cells[1]. AKR1B10-IN-1 (compound 4e)(0-20 uM; 96 hours) completely suppresses increased cell proliferation by the overexpressing AKR1B10 as well as the endogenous protein[1]. AKR1B10-IN-1 (compound 4e)(0-40 uM; 26 hours; pretreatment with AKR1B10-IN-1 for 2 hours, then incubated with CDDP for 24 hours) decreases the cell viability of CDDP-R-A549 cells in a dose-dependent manner[1]. Cell Viability Assay[1]. Cell Line: A549 cells, A549/1B10 cells (AKR1B10-stably overexpressing A549 cells). Concentration: 0, 10, 20uM. Incubation Time: 96 hours. Result: Dose-dependently suppressed the growth of both A549 and A549/1B10 cells, and statistically significant at 20 uM. Cell Viability Assay[1]. Cell Line: CDDP-resistance (cisplatin-resisitance) of A549 cells. Concentration: 0, 10, 20, 40uM. Incubation Time: Pretreatment with AKR1B10-IN-1 for 2 hours, then incubated with CDDP for 24 hours. Result: Decreased the cell viability of CDDP-R-A549 cells in a dose-dependent manner, and most obvious in the treatment of 40 uM.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Chk1-IN-6, CAS 2428423-77-0)
Structure
(Chk1-IN-6, CAS 2428423-77-0)
Structure
(Chk1-IN-6, CAS 2428423-77-0)
Structure
(Chk1-IN-6, CAS 2428423-77-0)
Related Product Information for AKR1B10-IN-1 biochemical
AKR1B10-IN-1 is a potent inhibitor of AKR1B10 (Aldo-Keto Reductase 1B10) with an IC 50 of 3.5 nM. AKR1B10-IN-1 suppresses proliferation, metastasis, and Cisplatin (CDDP) resistance of lung cancer cells.
References
1. Jin T, et al. Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile. J Med Chem. 2021 Oct 28;64(20):15069-15090.
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Product Notes
The AKR1B10-IN-1 (Catalog #AAA228148) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AKR1B10-IN-1, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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