Structure
(CDK7/9-IN-1, CAS 2747919-19-1)
Antitumor agent-23 Biochemical
Antitumor agent-23
Purity
98%
Synonyms
Antitumor agent-23; N/A; Antitumor agent-23 biochemical
Purity/Purification
98%
CAS
2355185-12-3
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
Antitumor agent-23 (0.001-100 uM; 5 days) inhibits lymphoma cells proliferation[1]. Antitumor agent-23 (2-70 nM; 72 hours) induces p53 protein expression and p53 lysine 382 acetylation (K382Ac-p53) in HPV-positive cervical cancer cell[1]. Cell Proliferation Assay[1]Cell Line: Lymphoma cell line GRANTA-519, KARPAS-422,KARPAS-299, RAMOS, DAUDI, RAJI Concentration: 0.001, 0.01, 0.1, 1, 10, 100 uM Incubation Time: 5 days. Result: The GI 50 s of 38, 48, 5, 27, 80, 28 nM for GRANTA-519, KARPAS-422,KARPAS-299, RAMOS, DAUDI, RAJI cells, respectively. Western Blot Analysis[1]Cell Line: HPV16-positive cervical cancer cell line (CaSki cell) Concentration: 2, 7, 20, and 70 nM Incubation Time: 72 hours. Result: Induction of p53 protein above baseline was evident at 7 nM already, acetylation of p53 lysine 382 was detectable at 20 nM.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(CDK7/9-IN-1, CAS 2747919-19-1)
Structure
(CDK7/9-IN-1, CAS 2747919-19-1)
Structure
(CDK7/9-IN-1, CAS 2747919-19-1)
Structure
(CDK7/9-IN-1, CAS 2747919-19-1)
Related Product Information for Antitumor agent-23 biochemical
Antitumor agent-23 is a potent anti-cancer agent with GI 50 s of 38, 48, 5, 27, 80, and 28 nM for lymphoma cell line GRANTA-519, KARPAS-422, KARPAS-299, RAMOS, DAUDI, and RAJI, respectively. Antitumoral activity.
References
1. Maria Carmen FERNANDEZ FIGUEROA, et al. Compounds useful for inhibiting cdk7. WO2021242602 A1.
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Product Notes
The Antitumor agent-23 (Catalog #AAA228336) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Antitumor agent-23, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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