Structure
(Anticancer agent 15, CAS 2710312-73-3)
ARD-61 biochemical
ARD-61
Purity
98%
Synonyms
ARD-61; N/A; ARD-61 biochemical
Purity/Purification
98%
CAS
2316837-08-6
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
ARD-61 (25, 50mg/kg/day; ip; for 75 days) effectively inhibits tumor growthin the MDA-MB-453 xenograft tumor model in male SCID mice[1]. ARD-61 (25mg/kg; ip; single dose) effectively and rapidly reduces the AR protein in the MDA-MB-453 xenograft tissue, with the effect persisting for at least 24h. ARD-61 is very effective in reducing the mRNA level of WNT7B in a time-dependent manner[1]. Animal Model: MDA-MB-453 xenograft tumor model in male SCID mice[1]. Dosage: 25, 50mg/kg. Administration: IP; daily; for 75 days. Result: Effectively inhibited tumor growth.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Anticancer agent 15, CAS 2710312-73-3)
Structure
(Anticancer agent 15, CAS 2710312-73-3)
Structure
(Anticancer agent 15, CAS 2710312-73-3)
Structure
(Anticancer agent 15, CAS 2710312-73-3)
Related Product Information for ARD-61 biochemical
ARD-61 is a highly potent, effective and specific PROTAC androgen receptor (AR) degrader. ARD-61 potently and effectively induces AR and progesterone receptors (PR) degradation in AR+ cancer cell lines. ARD-61 induces apoptosis and effectively induces tumor growth inhibition in the MDA-MB-453 xenograft model in mice.
References
1. Zhang K, et al. A Novel Anticancer Stem Cell Compound Derived from Pleuromutilin Induced Necroptosis of Melanoma Cells. J Med Chem. 2021 Nov 11;64(21):15825-15845.
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Product Notes
The ARD-61 (Catalog #AAA228317) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ARD-61, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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