Structure
(Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite, CAS 1391728-01-0)
Avanafil metabolite M4 Biochemical
Avanafil metabolite M4
Purity
98%
Synonyms
Avanafil metabolite M4; N/A; Avanafil metabolite M4 biochemical
Purity/Purification
98%
Solubility
Methanol: Soluble
DMSO: Soluble
<1mg/ml refers to the product slightly soluble or insoluble
DMSO: Soluble
<1mg/ml refers to the product slightly soluble or insoluble
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite, CAS 1391728-01-0)
Structure
(Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite, CAS 1391728-01-0)
Structure
(Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite, CAS 1391728-01-0)
Structure
(Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite, CAS 1391728-01-0)
Related Product Information for Avanafil metabolite M4 biochemical
Avanafil metabolite M4 is a major active metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil. Avanafil is metabolized by the cytochrome P450 (CYP450) isoforms CYP3A4 and CYP2C to the major metabolites avanafil metabolite M4 and avanafil metabolite M16, as well as minor metabolites. Avanafil metabolite M4 inhibits PDE5 with 18% of the potency of avanafil.
References
1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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Product Notes
The Avanafil metabolite M4 (Catalog #AAA227265) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Avanafil metabolite M4, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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