Structure
(Lesogaberan napadisylate, CAS 477956-38-0)
Bexirestrant Biochemical
Bexirestrant
Purity
98%
Synonyms
Bexirestrant; N/A; AZD-3355 napadisylate; Bexirestrant biochemical
Purity/Purification
98%
CAS
2505067-70-7
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
Bexirestrant (50mg/kg; p.o.; 28 days) shows a good efficacy in an MCF-Y537S xenograft[1]. Pharmacokinetic parameters in rat at 50 mg/kg p.o. dose[1]? T max (h) C max (ng/mL) AUC last (hr× ng/mL) AUC inf_obs (hr×ng/mL) T 1/2 (h) 4.00 343 7582 9804 26 Animal Model: Female athymic nude mice harboring subcutaneous MCF7-Y537S xenograft[1]. Dosage: 50mg/kg. Administration: p.o. for 28 days. Result: Showed 56% tumor growth inhibition compared to vehicle group after 28 days.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Lesogaberan napadisylate, CAS 477956-38-0)
Structure
(Lesogaberan napadisylate, CAS 477956-38-0)
Structure
(Lesogaberan napadisylate, CAS 477956-38-0)
Structure
(Lesogaberan napadisylate, CAS 477956-38-0)
Related Product Information for Bexirestrant biochemical
Bexirestrant is an orally active ER-alpha degrader. Bexirestrant can be used for the research of antiestrogen, antineoplastic.
References
1. Lehmann A, et al. (R)-(3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABAB receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action. J Pharmacol Exp Ther. 2009 Nov;331(2):504-12.
2. Tian J, et al. Repurposing Lesogaberan to Promote Human Islet Cell Survival and beta-Cell Replication. J Diabetes Res. 2017;2017:6403539.
2. Tian J, et al. Repurposing Lesogaberan to Promote Human Islet Cell Survival and beta-Cell Replication. J Diabetes Res. 2017;2017:6403539.
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Product Notes
The Bexirestrant (Catalog #AAA228481) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Bexirestrant, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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