Structure
(HOPan, CAS 18679-90-8)
BM-1197 biochemical
BM-1197
Purity
98%
Synonyms
BM-1197; N/A; BM-1197 biochemical
Purity/Purification
98%
CAS
1391107-89-3
Targets&IC50
Bcl-xL:5.2 nM (IC50), Bcl-2:3.5 nM (IC50)
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
BM-1197 (10 mg/kg; i.v. daily 5 days per week for 2 weeks) results in rapid and complete tumor regression in all 8 mice in H146 and H1963 tumor model[1]. BM-1197 (15 mg/kg; i.v.) causes thrombocytopenia in mice but the effect is reversible even at highly efficacious doses[1]. BM-1197 (10 mg/kg; i.v. qd) exerts a strong anti-tumor effect and is well tolerated in OCI-Ly8 xenograft models[2]. Animal Model: SCID mice bearing H146 cells[1]. Dosage: 10 mg/kg. Administration: I.v. daily 5 days per week for 2 weeks. Result: Remained tumor free for at least 32 days after the end of the treatment.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(HOPan, CAS 18679-90-8)
Structure
(HOPan, CAS 18679-90-8)
Structure
(HOPan, CAS 18679-90-8)
Structure
(HOPan, CAS 18679-90-8)
Related Product Information for BM-1197 biochemical
BM-1197 is a potent and selective inhibitor of dual Bcl-2/Bcl-xL, with IC 50 s of 3.5 nM and 5.2 nM for Bcl-2 and Bcl-xL, respectively. BM-1197 exhibits antitumor effects both in vitro and in vivo.
References
1. Mostert KJ, et al. The Coenzyme A Level Modulator Hopantenate (HoPan) Inhibits Phosphopantotenoylcysteine Synthetase Activity. ACS Chem Biol. 2021 Nov 19;16(11):2401-2414.
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Product Notes
The BM-1197 (Catalog #AAA227642) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BM-1197, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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