Structure
(Trx-red, CAS 2368978-96-3)
BMS-986224 biochemical
BMS-986224
Purity
98%
Synonyms
BMS-986224; N/A; NBL-SS perchlorate; BMS-986224 biochemical
Purity/Purification
98%
CAS
2055200-88-7
Targets&IC50
APJ receptor:0.3 nM (Kd)
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
BMS-986224 (0.192 mg/kg or 3mg/kg; SC infusion; daily;) in the RHR model increased stroke volume and cardiac output to levels seen in healthy animals but without preventing cardiac hypertrophy and fibrosis, effects differentiated from enalapril[1]. Animal Model: Male Sprague-Dawley rats (renal hypertensive rat model)[1]. Dosage: 0.192 mg/kg or 3mg/kg. Administration: SC infusion; daily; Initiated 3 days before surgery and continued for 7 days after surgery. Result: The achieved steady-state plasma concentrations during 10-day infusion were 102 and 2686 nmol/L at low dose and HD, respectively. At the low dose, BMS-986224 increased SV and CO without affecting other measured parameters, including the measured diastolic parameters, cardiac fibrosis, and heart weight in RHR.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Trx-red, CAS 2368978-96-3)
Structure
(Trx-red, CAS 2368978-96-3)
Structure
(Trx-red, CAS 2368978-96-3)
Structure
(Trx-red, CAS 2368978-96-3)
Related Product Information for BMS-986224 biochemical
BMS-986224 is a potent, selective and orally bioavailable APJ receptor agonist (K d = 0.3 nM). BMS-986224 exhibits similar receptor binding and signaling profile to (Pyr 1) apelin-13. BMS-986224 has the potential for the research of heart failure.
References
1. Huiyi Jia, et al. Fluorophore-Dependent Cleavage of Disulfide Bond Leading to a Highly Selective Fluorescent Probe of Thioredoxin. Anal Chem. 2019 Jul 2;91(13):8524-8531.
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Product Notes
The BMS-986224 (Catalog #AAA228056) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BMS-986224, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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