Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) Biochemical

Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)

Cat. Num. AAA227349

• Purity: 98%
• Synonyms: Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III); N/A; Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) biochemical

• Purity/Purification: 98%

• SMILES: [Cl-][Fe+3]123[N](C4=CC=CC=C4[N]2=CC5=CC=CC=C5[O-]3)=CC6=CC=CC=C6[O-]1
• Formula: C20H14ClFeN2O2
• CAS: 39916-28-4
• Solubility: DMSO: 14 mg/mL; ; PBS (pH 7.2): Partially Soluble; ; DMF: 20 mg/mL; ; Ethanol: 0.3mg/mL; <1mg/ml refers to the product slightly soluble or insoluble
• Preparation and Storage: Powder: -20 degree C for 3 years; In solvent: -80 degree C for 2 years

Structure

(Cl-amidine TFA, CAS 1043444-18-3)

Structure

(Cl-amidine TFA, CAS 1043444-18-3)

Related Product Information for Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) biochemical

Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) is an inducer of ferroptosis.1 It induces ferroptosis, but not apoptosis or necroptosis, in NB1 cancer cells when used at a concentration of 3 uM.1 Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) inhibits proliferation of BJAB, NALM-6, Jurkat, MelHO, and MCF-7 cancer cells (IC50s = 0.07, 2.5, 1.5, 3, and 5 uM, respectively), as well as NALM-6 cells resistant to daunorubicin and vincristine when used at concentrations ranging from 0.04 to 0.125 uM.2

Product Categories/Family for Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) biochemical

Others

References

1. Yuan Luo, et al. Inhibitors and Inactivators of Protein Arginine Deiminase 4: Functional and Structural Characterization. Biochemistry. 2006 Oct 3; 45(39): 11727-11736.
2. Chumanevich AA, et al. Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor. Am J Physiol Gastrointest Liver Physiol. 2011 Jun;300(6):G929-38.
3. Witalison EE, et al. Molecular targeting of protein arginine deiminases to suppress colitis and prevent colon cancer. Oncotarget. 2015 Nov 3;6(34):36053-62.
4. Biron BM, et al., Cl-Amidine Prevents Histone 3 Citrullination and Neutrophil Extracellular Trap Formation, and Improves Survival in a Murine Sepsis Model. J Innate Immun. 2017;9(1):22-32.