Structure
(pp60 (v-SRC) Autophosphorylation Site, Phosphorylated, CAS 176042-83-4)
CP-346086 dihydrate Biochemical | CP-346086 biochemical
CP-346086 dihydrate
Purity
98%
Synonyms
CP-346086 dihydrate; N/A; CP-346086 biochemical
Purity/Purification
98%
CAS
1262769-98-1
Targets&IC50
MTP:2.0 nM (IC50)
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
CP-346086 (1-100 mg/kg; oral gavage once daily for 2 weeks) reduces plasma total, VLDL, and LDL cholesterol and triglycerides in mice[1]. CP-346086 (25 mg/kg; a single p.o.) results in an almost complete inhibition of Tyloxapol-induced triglyceride accumulation in fasted rats[1]. CP-346086 (0.1-10 mg/kg; a single p.o.) reduces acute plasma triglyceride in mice[1]. Animal Model: B6CBAF1J mice[1]. Dosage: 1, 2, 10, 20, 100 mg/kg. Administration: Oral gavage once daily for 2 weeks. Result: Lowered total, VLDL, and LDL cholesterol and triglycerides dose dependently with 23%, 33%, 75%, and 62% reductions at 10 mg/kg/day.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(pp60 (v-SRC) Autophosphorylation Site, Phosphorylated, CAS 176042-83-4)
Structure
(pp60 (v-SRC) Autophosphorylation Site, Phosphorylated, CAS 176042-83-4)
Structure
(pp60 (v-SRC) Autophosphorylation Site, Phosphorylated, CAS 176042-83-4)
Structure
(pp60 (v-SRC) Autophosphorylation Site, Phosphorylated, CAS 176042-83-4)
Related Product Information for CP-346086 biochemical
CP-346086 dihydrate is a potent and orally active microsomal triglyceride transfer protein (MTP) inhibitor, with an IC 50 of 2.0 nM for human and rodent MTP. CP-346086 dihydrate can lower plasma cholesterol and triglycerides in vivo.
References
1. Liyun Ji, et al. Quantitative mass spectrometry combined with separation and enrichment of phosphopeptides by titania coated magnetic mesoporous silica microspheres for screening of protein kinase inhibitors. 2012 Mar 6;84(5):2284-91.
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Product Notes
The CP-346086 (Catalog #AAA227561) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CP-346086 dihydrate, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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