Structure
(MC-AAA-NHCH2OCH2COOH, CAS 2414594-28-6)
DI-87 biochemical
DI-87
Purity
98%
Synonyms
DI-87; N/A; DI-87 biochemical
Purity/Purification
98%
CAS
2107280-55-5
Targets&IC50
dCK:10.2 nM (EC50)
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
DI-87 (5-25 mg/kg; oral gavage) exhibits full dCK inhibition for 27 hours, and enzyme activity fully recovered by 36 hours with 25 mg/kg dose[1]. DI-87 (10-50 mg/kg; oral) has plasma concentrations of between 1 and 3 hours and plasma half-life of 4 hours[1]. DI-87 (10 mg/kg/day or 25 mg/kg/twice a day; oral; for 16-18 days) with thymidine (2 g/kg; ip; twice a day) results in reduced tumor growth in male NSG mice implanted with CEM tumors[1]. Animal Model: 8-12 week-old male or female NSG mice with CEM tumor xenografts[1]. Dosage: 5, 10, 25 mg/kg. Administration: Oral gavage. Result: The 25 mg/kg dose exhibited full dCK inhibition for 27 hours, and enzyme activity fully recovered by 36 hours. The 10 mg/kg dose resulted in full inhibition with recovery initiating at the 12 hours time point. The 5 mg/kg dose resulted in minimal dCK inhibition with rapid recovery. Animal Model: Female NSG mice with CEM tumors[1]. Dosage: 10, 25, or 50 mg/kg. Administration: Oral. Result: Had plasma concentrations of between 1 and 3 hours and plasma half-life of 4 hours. Had tumor concentrations lower than plasma and had a later, more sustained peak at 3-9 hours.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(MC-AAA-NHCH2OCH2COOH, CAS 2414594-28-6)
Structure
(MC-AAA-NHCH2OCH2COOH, CAS 2414594-28-6)
Structure
(MC-AAA-NHCH2OCH2COOH, CAS 2414594-28-6)
Structure
(MC-AAA-NHCH2OCH2COOH, CAS 2414594-28-6)
Related Product Information for DI-87 biochemical
DI-87 is an orally active and selective deoxycytidine kinase (dCK) inhibitor with an EC 50 of 10.2 nM. DI-87 has antitumor activity and is used in combination therapy against tumors expressing dCK.
References
1. Li W, et, al. Synthesis and Evaluation of Camptothecin Antibody-Drug Conjugates. ACS Med Chem Lett. 2019 Sep 6;10(10):1386-1392.
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Product Notes
The DI-87 (Catalog #AAA228124) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "DI-87, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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