Structure
(7-Methoxytryptamine, CAS 2436-04-6)
diABZI-C2-NH2 biochemical
diABZI-C2-NH2
Purity
98%
Synonyms
diABZI-C2-NH2; N/A; diABZI-C2-NH2 biochemical
Purity/Purification
98%
CAS
2137975-93-8
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
The author developed a linking strategy to synergize the effect of two symmetry-related amidobenzimidazole (ABZI)-based compounds to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function. Intravenous administration of a diABZI STING agonist to immunocompetent mice with established syngeneic colon tumours elicited strong anti-tumour activity, with complete and lasting regression of tumors[1]. diABZI-C2-NH2 is covalently immobilized on sepharose beads and is used to affinity-capture potential target proteins from a THP1 cell lysate[1].
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(7-Methoxytryptamine, CAS 2436-04-6)
Structure
(7-Methoxytryptamine, CAS 2436-04-6)
Structure
(7-Methoxytryptamine, CAS 2436-04-6)
Structure
(7-Methoxytryptamine, CAS 2436-04-6)
Related Product Information for diABZI-C2-NH2 biochemical
diABZI-C2-NH2, an active analogue containing a primary amine functionality, is a STING agonist.
References
1. Nauzer P. Dubash, Naveen K. Mangu, Apparao Satyam. (2004) Synthesis of 7-Alkoxy/Hydroxy-alpha-methyltryptamines. Synthetic Communications 34:10, pages 1791-1799.
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Product Notes
The diABZI-C2-NH2 (Catalog #AAA228151) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "diABZI-C2-NH2, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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