Structure
(Pulrodemstat, CAS 1821307-10-1)
EW-7195 biochemical
EW-7195
Purity
98%
Synonyms
EW-7195; N/A; LSD1-IN-7; CC-90011; EW-7195 biochemical
Purity/Purification
98%
CAS
1352609-28-9
Targets&IC50
ALK5:4.83 nM (IC50), p38alpha:1.5 uM (IC50)
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
EW7195 (40 mg/kg; i.p.; three times a week for 3/2.5 weeks) inhibits lung metastasis development in both 4T1 orthotopic xenograft and MMTV/cNeu transgenic mice[1]. Animal Model: MMTV/c-Neu mice[1]. Dosage: 40 mg/kg. Administration: I.p.; three times a week for 3 weeks. Result: Inhibited the metastasis of breast cancer cells to the lung. Animal Model: Balb/c xenograft model (10-weeks-old female Balb/c mice bearing 4T1 cells)[1]. Dosage: 40 mg/kg. Administration: I.p.; three times a week for 2.5 weeks. Result: Suppressed a lung metastasis in the Balb/c Xenograft model.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Pulrodemstat, CAS 1821307-10-1)
Structure
(Pulrodemstat, CAS 1821307-10-1)
Structure
(Pulrodemstat, CAS 1821307-10-1)
Structure
(Pulrodemstat, CAS 1821307-10-1)
Related Product Information for EW-7195 biochemical
EW-7195 is a potent and selective ALK5 (TGFbetaR1) inhibitor with an IC 50 of 4.83 nM. EW-7195 has 300-fold selectivity for ALK5 over p38alpha. EW-7195 efficiently inhibits TGF-beta1-induced Smad signaling, epithelial-to-mesenchymal transition (EMT) and breast tumour metastasis to the lung.
References
1. Toufike Kanouni, et al. Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1). J Med Chem. 2020 Dec 10;63(23):14522-14529.
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Product Notes
The EW-7195 (Catalog #AAA227610) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "EW-7195, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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