Structure
(L-803087 TFA, CAS 1786412-46-1)
Fabesetron Biochemical
Fabesetron
Purity
98%
Synonyms
Fabesetron; N/A; Fabesetron biochemical
Purity/Purification
98%
CAS
129300-27-2
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
Fabesetron (FK1052)(0.1 mg/kg p.o.) inhibits completely the increases in the colonic transit[1]. FK1052 (100 ug/kg) completely prevents emesis induced by cisplatin (18mg/kg, i.p.) in Suncus murinus[2]. Animal Model: Male Sprague-Dawley rats weighing 220 to 330 g and male ddy mice weighing 25 to 35 g were used[1]. Dosage: 0.1 mg/kg. Administration: P.O. Result: Significantly caused delay and its degree of inhibition was 33.8 +/- 4.8% by 0.1 mg/kg p.o. Animal Model: Suncus murinus of either sex (10-week-old; 30-70 g body weight)[2]. Dosage: 1, 10, and 100 ug/kg. Administration: Orally administered 30 min before the injection of cisplatin. Result: Inhibited cisplatininduced emesis in a dose-dependent manner, and no emesis was observed in three animals given the compound at 100 ug/kg.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(L-803087 TFA, CAS 1786412-46-1)
Structure
(L-803087 TFA, CAS 1786412-46-1)
Structure
(L-803087 TFA, CAS 1786412-46-1)
Structure
(L-803087 TFA, CAS 1786412-46-1)
Related Product Information for Fabesetron biochemical
Fabesetron (FK1052) is an orally active 5-HT 3 receptor antagonist with 5-HT 4 receptor antagonistic activity. Fabesetron (FK1052) can be used in the study for both acute and delayed emesis induced by cancer chemotherapy.
References
1. Rohrer SP, et al. Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science. 1998 Oct 23;282(5389):737-40.
2. Moneta D, et al. Somatostatin receptor subtypes 2 and 4 affect seizure susceptibility and hippocampal excitatory neurotransmission in mice. Eur J Neurosci. 2002 Sep;16(5):843-9.
2. Moneta D, et al. Somatostatin receptor subtypes 2 and 4 affect seizure susceptibility and hippocampal excitatory neurotransmission in mice. Eur J Neurosci. 2002 Sep;16(5):843-9.
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Product Notes
The Fabesetron (Catalog #AAA227578) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Fabesetron, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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