Structure
(HTL22562, CAS 2097085-63-5)
FSCPX biochemical
FSCPX
Purity
98%
Synonyms
FSCPX; N/A; FSCPX biochemical
Purity/Purification
98%
CAS
156547-56-7
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
FSCPX irreversibly blocks the binding of [ 3 H]-8-cyclopentyl-1,3dipropylxanthine ([ 3 H]DPCPX), with an IC 50 of 11.8+/-3.2 nM in DDT 1 MF2 cells[1]. FSCPX (20 uM; 48 h) attenuates protection from necrosis and apoptosis in A1AR-overexpressing LLC-PK1 cells[3]. FSCPX (2-20 uM; 48 h) reverses the upregulation of HSP27 mRNA and protein in A1AR-overexpressing LLC-PK1 cells without an effect on the mRNA or protein for HSP70[3].
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(HTL22562, CAS 2097085-63-5)
Structure
(HTL22562, CAS 2097085-63-5)
Structure
(HTL22562, CAS 2097085-63-5)
Structure
(HTL22562, CAS 2097085-63-5)
Related Product Information for FSCPX biochemical
FSCPX is a potent and selective irreversible antagonist of A 1 adenosine receptor (A 1 AR), with low nanomolar potency for binding to the A 1 AR. FSCPX could modify the effect of NBTI, a nucleoside transport inhibitor, by reducing the interstitial adenosine level in the guinea pig atrium.
References
1. Bucknell SJ, et al. Structure-Based Drug Discovery of N-((R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(((S)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3-d][1,3]oxazine]-1-carboxamide (HTL22562): A Calcitonin Gene-Related Peptide Receptor Antagonist for Acute Treatment of Migraine. J Med Chem. 2020 Jul 23;63(14):7906-7920.
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Product Notes
The FSCPX (Catalog #AAA227795) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "FSCPX, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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