Structure
(Propargyl-PEG1-THP, CAS 119096-95-6)
Gliotoxin-13C13 Biochemical
Gliotoxin-13C13
Purity
98%
Synonyms
Gliotoxin-13C13; N/A; Gliotoxin-13C13 biochemical
Purity/Purification
98%
Solubility
Acetonitrile: 3mg/mL
<1mg/ml refers to the product slightly soluble or insoluble
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
In vivo, gliotoxin (5 mg/kg) reduces LTB4plasma levels and blocks peritoneal neutrophil infiltration in a mouse model of peritonitis induced by zymosan A. It also inhibits geranylgeranyltransferase I and farnesyltransferase (IC50s = 17 and 80 uM, respectively).8
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Propargyl-PEG1-THP, CAS 119096-95-6)
Structure
(Propargyl-PEG1-THP, CAS 119096-95-6)
Structure
(Propargyl-PEG1-THP, CAS 119096-95-6)
Structure
(Propargyl-PEG1-THP, CAS 119096-95-6)
Related Product Information for Gliotoxin-13C13 biochemical
Gliotoxin-13C13is intended for use as an internal standard for the quantification of gliotoxin by GC- or LC-MS. Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains ofAspergillusand other fungi with diverse biological activities.1,2,3,4,5,6,7,8It inhibits 20S proteasomal chymotrypsin activity (IC50= 10 uM), blocking the degradation of IkappaBalpha and preventing the activation of NF-kappaB.2,3Gliotoxin induces apoptosis in monocytes and dendritic cells and reduces phagocytosis by neutrophils.4,5It suppresses viral infection by Nipah and Hendra virus in HEK293T cells (IC50s = 149 and 579 nM, respectively).6Under reducing conditions, gliotoxin inhibits leukotriene A4hydrolase epoxide hydrolase activity, but not aminopeptidase activity, and leukotriene B4synthesis in neutrophils and monocytes.7
References
1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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Product Notes
The Gliotoxin-13C13 (Catalog #AAA227071) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Gliotoxin-13C13, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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