Structure
(L-Hexaguluronic acid, CAS 183668-74-8)
GSK2332255B biochemical
GSK2332255B
Purity
98%
Synonyms
GSK2332255B; N/A; GSK2332255B biochemical
Purity/Purification
98%
CAS
1366233-41-1
Targets&IC50
rTRPC6:4 nM (IC50), rTRPC3:5 nM (IC50)
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
Nuclear factor of activated T cells (NFAT) activation by Ang II (angiotensin II) is blocked in a dose dependent manner by GSK255B (0.01, 0.1, and 1 uM) in HEK293T cells overexpressing TRPC3. GSK255B blocks NFAT activation by Ang II in HEK293T cells expressing a mutant TRPC6 channel with T70 and S322 mutated to glutamic acid (SETE)[1]. GSK255B (10 uM) blocks calcium entry stimulated by Phenylephrine (20 uM) in rat neonatal cardiac myocytes. GSK255B dose-dependent blockade of cell hypertrophy signaling triggered by angiotensin II or endothelin-1 in HEK293T cells as well as in neonatal and adult cardiac myocytes[1].
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(L-Hexaguluronic acid, CAS 183668-74-8)
Structure
(L-Hexaguluronic acid, CAS 183668-74-8)
Structure
(L-Hexaguluronic acid, CAS 183668-74-8)
Structure
(L-Hexaguluronic acid, CAS 183668-74-8)
Related Product Information for GSK2332255B biochemical
GSK2332255B is a potent, selective TRPC3 and TRPC6 antagonist with IC 50 s of 5 nM and 4 nM for rat TRPC3 and rat TRPC6. GSK2332255B shows >=100-fold selectivity for TRPC3/6 over other calcium-permeable channels.
References
1. R.A. Shirwaiker, et al. L-Guluronic Acid
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Product Notes
The GSK2332255B (Catalog #AAA227626) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GSK2332255B, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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