Structure
(D-Luciferin 6?-methyl ether, CAS 24404-90-8)
GSK973 biochemical
GSK973
Purity
98%
Synonyms
GSK973; N/A; 6?-Methoxyluciferin; GSK973 biochemical
Purity/Purification
98%
CAS
2138473-38-6
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
GSK973 (1 mg/kg; i.v.) treatment shows the CL, CI renal, V ss, and T 1/2 are 73 mL/min/kg, 4 mL/min/kg, 2.1L/kg, and 0.6 hours, respectively[1]. GSK973 (3mg/kg; p.o) treatment shows the F po of 48%[1]. Animal Model: Male Wistar Han Rats[1]. Dosage: 1 mg/kg (Pharmacokinetic Analysis). Administration: I.v. Result: The CL, CI renal, V ss, and T 1/2 were 73 mL/min/kg, 4 mL/min/kg, 2.1L/kg, and 0.6 hours, respectively.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(D-Luciferin 6?-methyl ether, CAS 24404-90-8)
Structure
(D-Luciferin 6?-methyl ether, CAS 24404-90-8)
Structure
(D-Luciferin 6?-methyl ether, CAS 24404-90-8)
Structure
(D-Luciferin 6?-methyl ether, CAS 24404-90-8)
Related Product Information for GSK973 biochemical
GSK973 is a highly selective, orally bioavailable inhibitor of the BD2s (second bromodomains) of the BET family, with a pIC 50 of 7.8 and a pK d of 8.7 for BRD4 BD2. GSK973 displays a 1600-fold selectivity for BRD4 BD2 over BRD4 BD1. GSK973 shows good potency against BRD2 BD2, BRD3 BD2, and BRDT BD2 (pIC 50 =7.4~7.8; pK d =8.3~8.5).
References
1. Giuseppe Meroni, et al. D-Luciferin, derivatives and analogues: synthesis and in vitro/in vivo luciferase-catalyzed bioluminescent activity. Volume 2009, Issue 1, Reviews and Accounts, pp. 265-288
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Product Notes
The GSK973 (Catalog #AAA228153) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GSK973, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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