Structure
(LY3027788 hydrochloride, CAS 1377615-55-8)
Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt) Biochemical
Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt)
Purity
98%
Synonyms
Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt); N/A; Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt) biochemical
Purity/Purification
98%
Solubility
H2O: Soluble
<1mg/ml refers to the product slightly soluble or insoluble
<1mg/ml refers to the product slightly soluble or insoluble
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(LY3027788 hydrochloride, CAS 1377615-55-8)
Structure
(LY3027788 hydrochloride, CAS 1377615-55-8)
Structure
(LY3027788 hydrochloride, CAS 1377615-55-8)
Structure
(LY3027788 hydrochloride, CAS 1377615-55-8)
Related Product Information for Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt) biochemical
Histone H3 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.3 sequence and is biotinylated via a C-terminal GK linker. Unlike histone H3.1 and H3.2, the histone H3.3 variant contains a serine residue at position 31 that is phosphorylated during late prometaphase and metaphase of mitosis. Histone H3 (21-44) also contains lysine residues at positions 23, 27, and 36 that are subject to methylation and acetylation, all of which have a role in the regulation of gene expression, and a serine residue at position 28 that is subject to phosphorylation during mitosis.
References
1. Witkin JM, et, al. Comparative Effects of LY3020371, a Potent and Selective Metabotropic Glutamate (mGlu) 2/3 Receptor Antagonist, and Ketamine, a Noncompetitive N-Methyl-d-Aspartate Receptor Antagonist in Rodents: Evidence Supporting the Use of mGlu2/3 Antagonists, for the Treatment of Depression. J Pharmacol Exp Ther. 2017 Apr;361(1):68-86.
2. Witkin JM, et, al. mGlu2/3 receptor antagonism: A mechanism to induce rapid antidepressant effects without ketamine-associated side-effects. Pharmacol Biochem Behav. 2020 Mar;190:172854.
2. Witkin JM, et, al. mGlu2/3 receptor antagonism: A mechanism to induce rapid antidepressant effects without ketamine-associated side-effects. Pharmacol Biochem Behav. 2020 Mar;190:172854.
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Product Notes
The Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt) (Catalog #AAA227246) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt), Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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