Structure
((S,R,S)-AHPC-PEG1-NH2, CAS 2241641-57-4)
Idroxioleic acid Biochemical
Idroxioleic acid
Purity
98%
Synonyms
Idroxioleic acid; N/A; VH032-PEG1-NH2; Idroxioleic acid biochemical
Purity/Purification
98%
CAS
182370-45-2
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
Idroxioleic acid ((R)-2-Hydroxyoleic acid; (R)-2-OHOA; 400 mg/kg; p.o.; daily; for 21 days) causes a reduction in tumor volume of about 20-25% after 21 days[1]. Animal Model: Male NUDE (Swiss) Crl:NU(Ico)-Foxn1nu mice (5 weeks old, 30-35 g) injected with A549 human lung cancer cells[1]. Dosage: 400 mg/kg. Administration: p.o.; daily; for 21 days. Result: Caused a reduction in tumor volume of about 20-25% after 21 days.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
((S,R,S)-AHPC-PEG1-NH2, CAS 2241641-57-4)
Structure
((S,R,S)-AHPC-PEG1-NH2, CAS 2241641-57-4)
Structure
((S,R,S)-AHPC-PEG1-NH2, CAS 2241641-57-4)
Structure
((S,R,S)-AHPC-PEG1-NH2, CAS 2241641-57-4)
Related Product Information for Idroxioleic acid biochemical
Idroxioleic acid ((R)-2-Hydroxyoleic acid; (R)-2-OHOA), the R enantiomer of (Rac)-Idroxioleic acid, is an orally active fatty acid that modulates the lipid composition and structure of the membranes. Idroxioleic acid has antitumor activities.
References
1. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.
2. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
2. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
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Product Notes
The Idroxioleic acid (Catalog #AAA227939) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Idroxioleic acid, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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