Structure
Ispinesib Biochemical
Ispinesib
Purity
98%
Synonyms
Ispinesib; N/A; SB-715992; SB 715992; SB715992; Ispinesib biochemical
Purity/Purification
98%
Suitability
10mM in DMSO
Target
Kinesin
Receptor
KSP (HsEg5)
Pathway
Cytoskeleton/Cell Adhesion Molecules
Chemical Name
Benzamide, N-(3-aminopropyl)-N-[(1R)-1-[7-chloro-3, 4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]-2-methylpropyl]-4-methyl
SMILES
O=C(N(CCCN)[C@@H](C(N1CC2=CC=CC=C2)=NC3=C(C=CC(Cl)=C3)C1=O)C(C)C)C4=CC=C(C)C=C4
Molecular Formula
C30H33ClN4O2
CAS Number
336113-53-2
Preparation and Storage
Store at -20°C for 1 year.
Structure
Structure
Related Product Information for Ispinesib biochemical
A potent, selective, cell-permeable, allosteric inhibitor of Eg5 (mitotic kinesin KSP) with Ki of 2.3nM; displays >10,000-fold selectivity for Eg5 over a range of other mitotic kinesins; induces a monopolar spindle phenotype, leading to the activation of a spindle assembly checkpoint, mitotic arrest, and subsequent cell death with GI50 of 20-80nM in colon, pancreas, prostrate, and lung cancer cells; demonstrates tumor regression of breast cancer cell xenografts in mice at 10mg/kg. Breast Cancer Phase 2 Clinical
Product Categories/Family for Ispinesib biochemical
References
1. Good JA, et al. J Med Chem. 2013 Mar 14; 56 (5):1878-93.
2. Purcell JW, et al. Clin Cancer Res. 2010 Jan 15; 16 (2):566-76.
3. Luo L, et al. Nat Chem Biol. 2007 Nov; 3 (11):722-6. Epub 2007 Oct 7.
2. Purcell JW, et al. Clin Cancer Res. 2010 Jan 15; 16 (2):566-76.
3. Luo L, et al. Nat Chem Biol. 2007 Nov; 3 (11):722-6. Epub 2007 Oct 7.
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Product Notes
The Ispinesib (Catalog #AAA201922) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Ispinesib, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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