Structure
(RB-3, CAS 2396639-11-3)
Ladostigil hemitartrate Biochemical
Ladostigil hemitartrate
Purity
98%
Synonyms
Ladostigil hemitartrate; N/A; Ladostigil hemitartrate biochemical
Purity/Purification
98%
CAS
209394-46-7
Targets&IC50
MAO-B:37.1 nM (IC50), AChE:31.8 nM (IC50)
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
Ladostigil (17 mg/kg; p.o. daily for 6 weeks) hemitartrate abolishes their hyperanxiety and depressive-like behaviour in the elevated plus maze (EPM) and forced swim tests (FST) tests in adulthood from puberty to prenatally-stressed rats[4]. Ladostigil (50 umol/kg; single p.o.) hemitartrate restores the loss of episodic memory in the object recognition test in rats[3]. Animal Model: Pathogen-free (SPF) Sprague-Dawley rats[4]. Dosage: 17 mg/kg. Administration: P.o. (added to the drinking water) daily for 6 weeks. Result: Inhibited brain MAO-A and B by more than 60%. Reduced hyperanxiety of male and female prenatally stressed (PS) rats in the EPM and depressive-like behaviour in the FST.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(RB-3, CAS 2396639-11-3)
Structure
(RB-3, CAS 2396639-11-3)
Structure
(RB-3, CAS 2396639-11-3)
Structure
(RB-3, CAS 2396639-11-3)
Related Product Information for Ladostigil hemitartrate biochemical
Ladostigil (TV-3326) hemitartrate is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC 50 s of 37.1 and 31.8 uM for MAO-B and AChE, respectively. Ladostigil hemitartrate exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil hemitartrate can be used for the research of depression and Alzheimer's disease.
References
1. Shirish Shukla, et al. Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain. Nat Chem Biol. 2021 Jul;17(7):784-793.
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Product Notes
The Ladostigil hemitartrate (Catalog #AAA228099) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Ladostigil hemitartrate, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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