Chemical Structure
LMP744 biochemical
LMP744 hydrochloride
Purity
>98%
Synonyms
LMP744; N/A; LMP744 hydrochloride; MJ-III65 hydrochloride; NSC706744 hydrochloride; LMP744 biochemical
Purity/Purification
>98%
Receptor
DNA-PKCS; Ku 70/80 heterodimer protein
SMILES
Cl.COc1cc2c3C(=O)c4cc5OCOc5cc4-c3n(CCCNCCO)c(=O)c2cc1OC
Target
Topoisomerase
Pathway
Cell Cycle/DNA Damage
Molecular Formula
C24H25ClN2O7
CAS Number
308246-57-3
Preparation and Storage
Store at -20°C
Chemical Structure
Chemical Structure
Related Product Information for LMP744 biochemical
LMP744 hydrochloride is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.?(In Vitro):LMP744 (0.1-5 µM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle.The GI50 value of LMP744 for NCI60 cells is 0.1 µM.?(In Vivo):LMP744 ?(10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity.
Product Categories/Family for LMP744 biochemical
References
1.Weterings E, et al. A novel small molecule inhibitor of the DNA repair protein Ku70/80. DNA Repair (Amst). 2016 Jul;43:98-106.
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Product Notes
The LMP744 (Catalog #AAA201963) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "LMP744, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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