Structure
(Ara-F-NAD+, CAS 133575-27-6)
Monohydroxy Melphalan (hydrochloride) Biochemical
Monohydroxy Melphalan (hydrochloride)
Purity
98%
Synonyms
Monohydroxy Melphalan (hydrochloride); N/A; Monohydroxy Melphalan (hydrochloride) biochemical
Purity/Purification
98%
Solubility
DMSO: Soluble
Methanol: Soluble
H2O: Soluble
<1mg/ml refers to the product slightly soluble or insoluble
Methanol: Soluble
H2O: Soluble
<1mg/ml refers to the product slightly soluble or insoluble
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Ara-F-NAD+, CAS 133575-27-6)
Structure
(Ara-F-NAD+, CAS 133575-27-6)
Structure
(Ara-F-NAD+, CAS 133575-27-6)
Structure
(Ara-F-NAD+, CAS 133575-27-6)
Related Product Information for Monohydroxy Melphalan (hydrochloride) biochemical
Monohydroxy melphalan is a DNA alkylating agent and a degradation product of melphalan. Monohydroxy melphalan is formed by the hydrolysis of melphalan in aqueous solutions, including cell culture medium and human plasma. It increases the level of DNA adducts in ML-1 myeloblastic leukemia cells in a concentration-dependent manner and induces cytotoxicity with an IC50 value of 28.1 ug/ml.
References
1. Berthelier V, et al. Human CD38 is an authentic NAD(P)+ glycohydrolase. Biochem J. 1998;330 (Pt 3Pt 3):1383-1390. doi:10.1042/bj3301383
2. Wang S, et al. Design, synthesis and SAR studies of NAD analogues as potent inhibitors towards CD38 NADase. Molecules. 2014;19(10):15754-15767. Published 2014 Sep 29.
2. Wang S, et al. Design, synthesis and SAR studies of NAD analogues as potent inhibitors towards CD38 NADase. Molecules. 2014;19(10):15754-15767. Published 2014 Sep 29.
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Product Notes
The Monohydroxy Melphalan (hydrochloride) (Catalog #AAA227198) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Monohydroxy Melphalan (hydrochloride), Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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