Structure
(Quetiapine sulfoxide hydrochloride, CAS T12619L2)
MS351 biochemical
MS351
Purity
98%
Synonyms
MS351; N/A; Quetiapine S-oxide hydrochloride; Quetiapine sulfoxide hydrochloride (329216-63-9 free base); MS351 biochemical
Purity/Purification
98%
SMILES
Cl.Cc1ccccc1Cn1c2ccccc2n(CC(O)c2ccc(Cl)c(Cl)c2)c1=N
Formula
C23H22Cl3N3O
CAS
472984-79-5
Solubility
DMSO: 15 mg/mL
DMF: 0.33mg/mL
DMSO:PBS (pH 7.2)(1:10): 0.09 mg/mL
Ethanol: 0.1 mg/mL
<1mg/ml refers to the product slightly soluble or insoluble
DMF: 0.33mg/mL
DMSO:PBS (pH 7.2)(1:10): 0.09 mg/mL
Ethanol: 0.1 mg/mL
<1mg/ml refers to the product slightly soluble or insoluble
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Quetiapine sulfoxide hydrochloride, CAS T12619L2)
Structure
(Quetiapine sulfoxide hydrochloride, CAS T12619L2)
Structure
(Quetiapine sulfoxide hydrochloride, CAS T12619L2)
Structure
(Quetiapine sulfoxide hydrochloride, CAS T12619L2)
Related Product Information for MS351 biochemical
MS351 is an antagonist of chromobox 7 (CBX7) that acts by binding the CBX7 chromodomain. It enhances the binding of long noncoding RNA to the CBX7 chromodomain when used at 25 uM. MS351 induces transcriptional derepression of CBX7 target genes, including p16 (INK4a), in mouse embryonic stem cells and human prostate cancer PC3 cells.
Product Categories/Family for MS351 biochemical
References
1. Remmerie B, et al. Comparison of Capillary and Venous Drug Concentrations After Administration of a Single Dose of Risperidone, Paliperidone, Quetiapine, Olanzapine, or Aripiprazole. Clin Pharmacol Drug Dev. 2016 Nov;5(6):528-537.
2. Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66.
2. Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66.
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Product Notes
The MS351 (Catalog #AAA227042) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MS351, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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