Structure
(Tunlametinib, CAS 1801756-06-8)
MSDC-0602K biochemical
MSDC-0602K
Purity
98%
Synonyms
MSDC-0602K; N/A; MSDC-0602K biochemical
Purity/Purification
98%
CAS
1314533-27-1
Targets&IC50
PPAR-gamma:18.25 uM (IC50)
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
Diabetic db/db and MS-NASH mice are treated with MSDC-0602K by oral gavage, Liraglutide by s.c. injection, or combination MSDC-0602K + Liraglutide. This combination treatment may be an effective therapeutic strategy for diabetes and non-alcoholic steatohepatitis (NASH). Animal Model: Five-week-old male db/db mice on C57BL/6J background and age/sex-matched db/+ control mice[1]. Dosage: 30 mg/kg MSDC-0602K; 0.2 mg/kg Liraglutide (obtained from MedChemExpress; HY-P0014). Administration: MSDC-0602K gavage daily, Liraglutide s.c. injection every other day, or combined MSDC-0602K+ Liraglutide. Result: MSDC-0602K corrected glycemia and reduced insulinemia when given alone, or in combination with Liraglutide. However, MSDC-0602K + Liraglutide combination more significantly improved glucose tolerance and liver histology.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Tunlametinib, CAS 1801756-06-8)
Structure
(Tunlametinib, CAS 1801756-06-8)
Structure
(Tunlametinib, CAS 1801756-06-8)
Structure
(Tunlametinib, CAS 1801756-06-8)
Related Product Information for MSDC-0602K biochemical
MSDC-0602K (Azemiglitazone potassium), a PPARgamma -sparing thiazolidinedione (Ps-TZD), binds to PPARgamma with the IC 50 of 18.25 uM. MSDC-0602K modulates the mitochondrial pyruvate carrier (MPC). MSDC-0602K can be used for the research of fatty liver including dysfunctional lipid metabolism, inflammation, and insulin resistance. MSDC-0602K, an insulin sensitizer, improves insulinemia and fatty liver disease in mice, alone and in combination with Liraglutide.
References
1. International Nonproprietary Names for Pharmaceutical Substances (INN)
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Product Notes
The MSDC-0602K (Catalog #AAA227586) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MSDC-0602K, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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