Structure
(ZXH-4-137, CAS 2711006-74-3)
NVP-BSK805 trihydrochloride Biochemical
NVP-BSK805 trihydrochloride
Purity
98%
Synonyms
NVP-BSK805 trihydrochloride; N/A; NVP-BSK805 trihydrochloride biochemical
Purity/Purification
98%
CAS
2320258-95-3
Targets&IC50
FL JAK2 wt:0.58 nM (IC50), JAK2 JH1:0.48 nM (IC50), TYK2 JH1:18.68 nM (IC50), JAK1 JH1:31.68 nM (IC50), JAK2(V617F):0.56 nM (IC50)
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
NVP-BSK805 trihydrochloride (BSK 805; 150 mg/kg, p.o.) blocks STAT5 phosphorylation, splenomegaly, and leukemic cell spreading in a Ba/F3 JAK2 V617F cell-driven mouse model[1]. NVP-BSK805 trihydrochloride (50, 75, and 100 mg/kg, p.o.) also suppresses rhEpo-mediated polycythemia and splenomegaly in BALB/c mice[1].
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(ZXH-4-137, CAS 2711006-74-3)
Structure
(ZXH-4-137, CAS 2711006-74-3)
Structure
(ZXH-4-137, CAS 2711006-74-3)
Structure
(ZXH-4-137, CAS 2711006-74-3)
Related Product Information for NVP-BSK805 trihydrochloride biochemical
NVP-BSK805 trihydrochloride trihydrochloride is an ATP-competitive JAK2 inhibitor, with IC 50 s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively.
References
1. Powell CE, et al. Selective degradation-inducing probes for studying cereblon (CRBN) biology. RSC Med Chem. 2021 Jul 6;12(8):1381-1390.
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Product Notes
The NVP-BSK805 trihydrochloride (Catalog #AAA228320) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "NVP-BSK805 trihydrochloride, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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